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首页> 外文期刊>Saudi Journal of Biological Sciences >Neurophysiological study on possible protective and therapeutic effects of Sidr (Zizyphus spina-christi L.) leaf extract in male albino rats treated with pentylenetetrazol
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Neurophysiological study on possible protective and therapeutic effects of Sidr (Zizyphus spina-christi L.) leaf extract in male albino rats treated with pentylenetetrazol

机译：戊二唑对雄性白化病大鼠Sidr（Zizyphus spina-christi L.）叶提取物可能的保护和治疗作用的神经生理学研究

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In this study, anti-convulsant effect of Sidr leaf extract was examined by using pentylenetetrazol (PTZ) model on male albino rat by evaluating the changes in norepinephrine (NE), dopamine (DA) and serotonin (5-HT) contents in different brain regions (cerebellum, brainstem, striatum, cerebral cortex, hypothalamus and hippocampus). The administration of subconvulsive dose of PTZ (40mg/kg i.p.) every other day for 9days caused a significant decrease in monoamine content in different brain areas, this is may be due to the increase in nitric oxide levels, although antagonized the GABAA receptors which led to neurotransmitter release so the content is decreased. Administration of PTZ after treatment with Sidr (50mg/kg i.p.) leaf extract for 3weeks as a protective group and administration of Sidr leaf extract for 3weeks after treatment of PTZ as a therapeutic group caused significant increase in NE, DA, and 5-HT contents in all tested brain regions at most of the time intervals studied. This may be due to the presence of peptide and cyclopeptide alkaloids in the extract which inhibit neurotransmitter activity which led to the inhibition of neurotransmitter release. From these results, we can say that the Sidr leaf extract has neuroprotective and therapeutic roles against pentylenetetrazol convulsant effect.
机译：本研究采用戊四氮（PTZ）模型对雄性白化病大鼠的Sidr叶提取物具有抗惊厥作用，通过评估不同大脑中去甲肾上腺素（NE），多巴胺（DA）和5-羟色胺（5-HT）含量的变化区域（小脑，脑干，纹状体，大脑皮层，下丘脑和海马体）。连续9天每隔一天服用一次惊厥剂量的PTZ（40mg / kg ip），导致不同脑区单胺含量显着下降，这可能是由于一氧化氮水平升高，尽管拮抗了GABAA受体，会释放神经递质，因此含量会减少。将Sidr（50mg / kg ip）叶提取物作为保护组治疗3周后施用PTZ，将PTZ作为治疗组治疗后3周施用Sidr叶提取物导致NE，DA和5-HT含量显着增加在研究的大多数时间间隔内，所有受测的大脑区域都处于正常状态。这可能是由于提取物中存在抑制神经递质活性的肽和环肽生物碱，从而抑制了神经递质的释放。从这些结果，我们可以说Sidr叶提取物对戊四氮惊厥作用具有神经保护和治疗作用。

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