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Effect of Cynomorium total flavone on depression model of perimenopausal rat

机译：锁阳总黄酮对围绝经期大鼠抑郁模型的影响

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Purpose: To observe the effect of cynomorium total flavone on the depression model of perimenopausal rat and to analyze the action characteristics of cynomorium total flavone on depression of rat with perimenopausal syndrome. Method: Duplicate the model of rat with perimenopausal depression based on the combined method of incomplete castration and chronic stimulation, and keep drug administration for 35d. And then measure related behavior indicators and the change of biochemical index level in serum and brains; measure the estrogen/androgen receptor (ER/AR) in related tissues and the ERmRNA expression in hypothalamus. Result: It can be seen that cynomorium total flavone can significantly improve the behavior indicators of rat with perimenopausal depression; obviously or significantly change the level of related biomedical indexes in serum and brains of perimenopausal depressed rat; obviously or significantly increase the expression of ER/AR in related tissues of perimenopausal depressed rat; obviously or significantly increase the ERmRNA expression in hypothalamus. Conclusion: Cynomorium total flavone can adjust hypothalamic-pituitary-gonadal axis by increasing E2, and make related biomedical indexes and hormone receptors tend to be normal, so as to relieve perimenopausal syndrome and perimenopausal syndrome with depression.
机译：目的：观察锁阳总黄酮对围绝经期大鼠抑郁模型的影响，并分析锁阳总黄酮对围绝经期大鼠抑郁的作用特征。方法：采用不完全去势与慢性刺激相结合的方法复制绝经后抑郁症大鼠模型，并维持给药35d。然后测量相关的行为指标以及血清和大脑中生化指标水平的变化;测量相关组织中的雌激素/雄激素受体（ER / AR）以及下丘脑中ERmRNA的表达。结果：可见锁阳总黄酮能显着改善绝经后抑郁大鼠的行为指标。明显或显着改变围绝经期抑郁症大鼠血清和脑中相关生物医学指标的水平;明显或显着增加围绝经期抑郁症大鼠相关组织中ER / AR的表达;明显或显着增加下丘脑的ERmRNA表达。结论：锁阳总黄酮可通过增加E2来调节下丘脑-垂体-性腺轴，并使相关的生物医学指标和激素受体趋于正常，从而缓解围绝经期综合征和伴抑郁症的围绝经期综合征。

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