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首页> 外文期刊>Saudi Journal of Biological Sciences >Effects of compound lobelia oral liquid on acute pharyngitis rabbits model
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Effects of compound lobelia oral liquid on acute pharyngitis rabbits model

机译：复方山茶口服液对急性咽炎兔模型的影响

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Aims Explore the effect of compound lobelia oral liquid on acute pharyngitis rabbits model caused by ammonium hydroxide, evaluate its curative effect. Methods Acute pharyngitis rabbit model was prepared by ammonia spray at pharyngeal. After 1?h of the last administration, score the pharyngeal tissue symptoms of rabbits under the condition of naked eyes (score according to the score criteria). Then, take blood from the marginal auricular vein for routine blood tests and serum TNF-α level measure. Take pharyngeal tissue for HE staining, and observe its pathological changes under the microscope. Results Compared with the blank group, the pharyngeal tissue symptom score and serum TNF-α level in the model group were significantly increased ( P ??0.01). The results of blood routine showed that the number of white blood cells and lymphocytes in the model group increased significantly ( P ??0.01), and neutrophilic granulocyte percentage decreased significantly ( P ??0.01). The infiltration of inflammatory cells in the pharynx tissue was obvious and pathological changes were observed. Compared with the model group, large, middle and small doses of compound lobelia oral liquid group could reduce the scores of pharyngeal tissue symptoms in rabbits with acute pharyngitis induced by ammonia. The large and middle dose compound lobelia oral liquid group could significantly reduce serum TNF-α level and neutrophilic granulocyte percentage, significantly increase the number of white blood cells and lymphocytes ( P ??0.01); The small dose compound lobelia oral liquid group could significantly reduce the number of white blood cells and lymphocytes ( P ??0.01), there was an increasing tendency to neutrophils and a decreasing tendency to serum TNF-α, but no statistical significance. The large, middle and small doses of compound lobelia oral liquid group all could improve the pathological changes of pharyngeal tissue inflammatory infiltration. Conclusion Compound lobelia oral liquid has a good effect on rabbit acute pharyngitis model caused by ammonia.
机译：目的探讨复方山茶口服液对氢氧化铵致急性咽炎兔模型的治疗作用，评价其疗效。方法采用氨水喷雾法制备急性咽炎兔模型。在最后一次给药1小时后，在裸眼条件下对兔子的咽部组织症状进行评分（根据评分标准评分）。然后，从耳廓边缘静脉抽取血液进行常规血液检查和血清TNF-α水平的测量。取咽组织进行HE染色，并在显微镜下观察其病理变化。结果与空白组相比，模型组的咽组织症状评分和血清TNF-α水平明显升高（P <0.01）。血液常规结果显示，模型组白细胞和淋巴细胞数目显着增加（P≤0.01），嗜中性粒细胞百分比显着下降（P≤0.01）。咽部组织中炎性细胞浸润明显，并观察到病理变化。与模型组相比，大，中，小剂量复方山茶口服液组可降低氨致急性咽炎兔的咽部组织症状评分。大中剂量复方山茶口服液组可显着降低血清TNF-α水平和中性粒细胞百分比，显着增加白细胞和淋巴细胞数目（P <0.01）;小剂量复方山茶口服液组可以显着减少白细胞和淋巴细胞的数量（P <0.01），中性粒细胞的增加趋势和血清TNF-α的下降趋势，但无统计学意义。大，中，小剂量复方山茶口服液组均可改善咽部组织炎症浸润的病理变化。结论复方山茶口服液对氨水致兔急性咽炎有较好的治疗作用。

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