...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Saudi Journal of Biological Sciences >Effect of Total Alkali in Leonuri Herba on rat ear acne model of serum IL-6 level, Thymus and Spleen Tissue Morphology
【24h】

Effect of Total Alkali in Leonuri Herba on rat ear acne model of serum IL-6 level, Thymus and Spleen Tissue Morphology

机译：益母草中总碱对大鼠耳疮模型血清IL-6水平，胸腺和脾组织形态的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To investigate the effect of Total Alkali in Leonuri Herba (TALH) on rat ear acne model of serum IL-6 level, Thymus and Spleen Tissue Morphology. The rats were divided into the TALH group at high, medium and low doses (200mgkg^-^1, 100mg.kg^-^1, 50mg.kg^-^1), the tanshinone group (360mg.kg^-^1), model group and the blank group. All the rats were administrated once a day for 14days. At the same time on the first day, the rats in the blank group were injected normal saline in the stomach and also had intradermal injection of sterile saline in the auricle. The rats in other groups (model group were lavaged with physiological saline) were injected intradermally auricle spare Staphylococcus epidermidis bacteria liquid. After the injection, the rat ear swelling rate was calculated for 5 consecutive days in terms of rat auricle thickness measurement. 1h after the last administration, the eyeball blood was removed, centrifuged to separate serum, and measured to be at serum IL-6 level; The tissue sections of thymus and spleen were observed according to morphology criteria. Compared with the blank group, the level of IL-6 in serum of the rats in the model group was remarkably higher, and those in the thymus and spleen groups were remarkably lower, indicating the rat ear acne model is successful. Compared with the model group, the rats in the TALH group can remarkably make serum IL-6 level decrease, causing significant thymus cortical thickening and increased spleen sections, and remarkably increasing the lymphocytes of thymus and spleen. The effect of large dose in the TALH group is the best and increases with the increase of the dose and curative effect. The TALH treatment of acne may be related to the reduction of serum IL-6 levels and the resistance of the atrophy of the thymus and spleen on the rat ear acne model.
机译：为了研究益母草中总碱对大鼠耳痤疮血清IL-6水平，胸腺和脾组织形态的影响。高，中，低剂量将大鼠分为TALH组（200mgkg ^-^ 1、100mg.kg ^-^ 1、50mg.kg ^-^ 1），丹参酮组（360mg.kg ^-^ 1） ），模型组和空白组。每天一次给予所有大鼠14天。在第一天的同一时间，空白组的大鼠在胃中注射生理盐水，并且在耳廓内皮内注射无菌盐水。给其他组（模型组灌洗生理盐水）的大鼠皮内注射耳廓备用表皮葡萄球菌细菌液。注射后，根据大鼠耳廓厚度的测量，连续5天计算大鼠耳肿胀率。最后一次给药后1h，除去眼球血液，离心分离出血清，并测定其血清IL-6水平。根据形态学标准观察胸腺和脾的组织切片。与空白组相比，模型组大鼠血清IL-6水平明显升高，胸腺和脾脏组血清IL-6水平明显降低，说明大鼠耳痤疮模型成功。与模型组相比，TALH组大鼠可明显降低血清IL-6水平，引起明显的胸腺皮质增厚和脾脏切片增加，并显着增加胸腺和脾脏淋巴细胞。 TALH组大剂量的效果最好，并随着剂量和疗效的增加而增加。 TALH治疗痤疮可能与大鼠耳部痤疮模型的血清IL-6水平降低以及胸腺和脾萎缩的抵抗有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号