...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Oxidative Medicine and Cellular Longevity >Reactive Oxygen Species and Age-Related Genes p66Shc, Sirtuin, FoxO3 and Klotho in Senescence
【24h】

Reactive Oxygen Species and Age-Related Genes p66Shc, Sirtuin, FoxO3 and Klotho in Senescence

机译：活性氧和衰老相关基因p66Shc，Sirtuin，FoxO3和Klotho的衰老

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Reactive oxygen species (ROS) superoxide and hydrogen peroxide perform important signaling functions in many physiological and pathophysiological processes. Cell senescence and organismal age are not exemptions. Aging-regulating genesp66shc, Sirtuin, FOXO3aandKlothoare new important factors which are stimulated by ROS signaling. It has been shown that ROS participate in initiation and prolongation of gene-dependent aging development. ROS also participate in the activation of protein kinases Akt/PKB and extracellular signal-regulated kinase ERK, which by themselves or through gene activation stimulates or retards cell senescence. Different retarding/stimulating effects of ROS might depend on the nature of signaling species—superoxide or hydrogen peroxide. Importance of radical anion superoxide as a signaling molecule with “super-nucleophilic” properties points to the possibility of the use of superoxide scavengers (SOD mimetics, ubiquinones and flavonoids) for retarding the development of aging.
机译：活性氧（ROS）超氧化物和过氧化氢在许多生理和病理生理过程中执行重要的信号传导功能。细胞衰老和机体年龄都不例外。衰老调节基因p66shc，Sirtuin，FOXO3a和Klotho是ROS信号刺激的新的重要因素。已经证明ROS参与基因依赖性衰老发展的开始和延长。 ROS还参与蛋白激酶Akt / PKB和细胞外信号调节激酶ERK的激活，它们本身或通过基因激活来刺激或延缓细胞衰老。 ROS的不同阻滞/刺激作用可能取决于信号物质（超氧化物或过氧化氢）的性质。自由基阴离子超氧化物作为具有“超亲核”性质的信号分子的重要性，指出了使用超氧化物清除剂（SOD模拟物，泛醌和类黄酮）来延缓衰老的可能性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号