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首页> 外文期刊>Saudi Journal of Anaesthesia >Role of tranexamic acid in reducing postoperative blood loss and transfusion requirement in patients undergoing hip and femoral surgeries
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Role of tranexamic acid in reducing postoperative blood loss and transfusion requirement in patients undergoing hip and femoral surgeries

机译：氨甲环酸在减少髋和股骨手术患者术后失血量和输血量方面的作用

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Context: Pharmacological agents are used to reduce postoperative blood loss. Aims: To assess the effects of tranexamic acid on prevention of bleeding and requirement of blood transfusion after major hip and femoral surgeries. Settings and Design: A prospective, randomized, double blinded study was conducted in the tertiary care teaching hospital. Methods: Ninety ASA grade I-II patients undergoing hip fracture surgery were included in this prospective study. Forty-five patients received tranexamic acid (TA) given in a bolus dose of 500 mg 15 min before surgical incision followed by continuous infusion. The remaining, 45 patients were allocated as a control group. Postoperative bleeding (volume of blood in the drain), percentage fall of hemoglobin, transfusions and complications were recorded. Results: Mean volume of blood in the drain was 39.33±10.09 ml (mean±SD) as compared to 91.11±17.61 ml in placebo group showing a P<0.001. Mean percentage fall in Hb at day 0 was 2.99±3.45 in the study group as compared to 7.70±6.05 in the placebo group ( P <0.001), and fall at day 2 in the study group was 0.35±0.74, compared to 2.72±2.70 in the placebo group ( P <0.001). The number of patients required blood transfusions were lower in the study group than in the placebo group ( P =0.01). Conclusions: We conclude that tranexamic acid significantly reduces postoperative blood loss and transfusion requirements during major hip and femoral surgeries.
机译：背景：药物可减少术后失血。目的：评估氨甲环酸对预防大髋和股骨手术后出血和输血的影响。设置与设计：在三级教学医院进行了一项前瞻性，随机，双盲研究。方法：该前瞻性研究纳入了90例接受髋部骨折手术的ASA I-II级患者。四十五名患者在手术切口前15分钟接受了氨甲环酸（TA）推注，剂量为500 mg，然后连续输注。其余45例患者被分配为对照组。记录术后出血（排出的血液量），血红蛋白下降百分比，输血和并发症。结果：引流中的平均血液量为39.33±10.09 ml（平均值±标准差），而安慰剂组为91.11±17.61 ml，P <0.001。研究组在第0天的Hb平均下降百分比为2.99±3.45，相比之下，安慰剂组为7.70±6.05（P <0.001），研究组在第2天的平均下降率为0.35±0.74，相比之下为2.72±安慰剂组为2.70（P <0.001）。研究组中需要输血的患者人数低于安慰剂组（P = 0.01）。结论：我们得出的结论是，氨甲环酸显着降低了重大髋部和股骨手术中的术后失血量和输血量。

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