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首页> 外文期刊>Saudi journal of kidney diseases and transplantation : >Serum cystatin C levels in Healthy Nigerian neonates: Is there a need for normative values in Nigerian babies?
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Serum cystatin C levels in Healthy Nigerian neonates: Is there a need for normative values in Nigerian babies?

机译：尼日利亚健康新生儿的血清胱抑素C水平：尼日利亚婴儿是否需要规范值？

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Cystatin C is an endogenous marker of renal function. Normal reference values have been documented in neonates outside Africa, but no study has been documented in African neonates. With reports that race may affect serum cystatin C values, this study was carried out to generate normal values in apparently healthy term neonates at birth and three days of life neonates in Nigeria. This was a hospital-based prospective study. A cohort of 120 apparently healthy term neonates were recruited at birth. Serum cystatin C was measured from the cord blood at birth and venous blood when they were three days old using enzyme-linked immunosorbent assay (ELISA) method. The mean serum cystatin C values for cord blood and 3rd day venous samples were 1.67 ± 0.52 mg/L and 1.62 ± 0.52 mg/L, respectively (P = 0.87). The cord blood and 3rd day serum cystatin C values for males were 1.67 ± 0.47 mg/L and 1.68 ± 0.51 mg/L, respectively (P = 0.77) and the values for females were 1.68 ± 0.56 mg/L and 1.58 ± 0.52 mg/L, respectively (P = 07.22). The serum cystatin C levels were similar among the different birth weight groups and gestational age (P >0.05). The cord blood and 3rd day serum cystatin C values were similar. Serum cystatin C values were independent of gender and birth weight of neonates. The values of serum cystatin C in Nigerian neonates were comparable to that reported for neonates in other regions of the world. It is recommended that ELISA technique may be reliably used to measure serum cystatin C levels in neonates.
机译：胱抑素C是肾功能的内源性标志物。在非洲以外的新生儿中已记录了正常参考值，但在非洲新生儿中未进行任何研究。关于种族可能会影响血清胱抑素C值的报道，这项研究旨在在尼日利亚出生的显然健康的足月新生儿和生命中三天的新生儿中产生正常值。这是一项基于医院的前瞻性研究。出生时招募了120名显然健康的足月新生儿。使用酶联免疫吸附法（ELISA）从出生时的脐血和三天大时的静脉血中测量血清胱抑素C。脐血和第3天静脉样品的平均血清半胱氨酸蛋白酶抑制剂C值分别为1.67±0.52 mg / L和1.62±0.52 mg / L（P = 0.87）。男性的脐血和第3天的血清胱抑素C值分别为1.67±0.47 mg / L和1.68±0.51 mg / L（P = 0.77），而女性则为1.68±0.56 mg / L和1.58±0.52 mg / L（P = 07.22）。不同出生体重组和胎龄的血清胱抑素C水平相似（P> 0.05）。脐血和第3天血清半胱氨酸蛋白酶抑制剂C值相似。血清胱抑素C值与新生儿的性别和出生体重无关。尼日利亚新生儿的血清胱抑素C值可与世界其他地区的新生儿相比。建议可将ELISA技术可靠地用于测量新生儿的血清胱抑素C水平。

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