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Factors affecting intradiscal pressure measurement during in vitro biomechanical tests

机译：体外生物力学测试中影响椎间盘内压力测量的因素

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Objectives To assess the reliability of intradiscal pressure measurement during in vitro biomechanical testing. In particular, the variability of measurements will be assessed for repeated measures by considering the effect of specimens and of freezing/thawing cycles. Methods Thirty-six functional units from 8 porcine spines (S1: T7-T8, S2: T9-T10, S3: T12-T11, S4: T14-T13, S5: L1-L2 and S6: L3-L4) have been used. The intervertebral discs were measured to obtain the frontal and sagittal dimensions. These measurements helped locate the center of the disc where a modified catheter was positioned. A fiber optic pressure sensor (measuring range: -0.1 to 17 bar) (360HP, SAMBA Sensors, Sweden) was then inserted into the catheter. The specimens were divided into 3 groups: 1) fresh (F), 2) after one freeze/thaw cycle (C1) and 3) after 2 freeze/thaw cycles (C2). These groups were divided in two, depending on whether specimens were subjected to 400 N axial loading or not. Ten measurements (insertion of the sensor for a period of one minute, then removal) were taken for each case. Statistical analyses evaluated the influence of porcine specimen and the vertebral level using a MANOVA. The effect of repeated measurements was evaluated with ANOVA. The difference between freeze/thaw cycles were analysed with U Mann-Whitney test (P≤0.05). Results Without axial loading, the F group showed 365 mbar intradiscal pressure, 473 mbar for the C1 group, and 391 mbar for the C2 group. With 400N axial load, the F group showed intradiscal pressure of 10610 mbar, the C1 group 10132 mbar, the C2 group 12074 mbar. The statistical analysis shows a significant influence of the porcine specimen (pConclusions The results tend to support that freezing/thawing cycles can affect intradiscal pressure measurement with significant inter-specimen variability. The use of the same specimen as its own control during in vitro biomechanical testing could be recommended.
机译：目的评估体外生物力学测试过程中椎间盘内压力测量的可靠性。特别是，将通过考虑样本的影响和冷冻/解冻循环的影响来评估重复测量的测量变异性。方法使用了来自8个猪棘的36个功能单元（S1：T7-T8，S2：T9-T10，S3：T12-T11，S4：T14-T13，S5：L1-L2和S6：L3-L4） 。测量椎间盘以获得额和矢状尺寸。这些测量有助于将椎间盘的中心定位在放置了改良导管的位置。然后将光纤压力传感器（测量范围：-0.1至17 bar）（360HP，SAMBA Sensors，瑞典）插入导管中。将标本分为3组：1）新鲜（F），2）一个冷冻/解冻循环后（C1）和3）两个冷冻/解冻循环后（C2）。根据样品是否承受400 N轴向载荷，将它们分为两部分。每种情况下进行十次测量（将传感器插入一分钟，然后取出）。统计分析使用MANOVA评估了猪标本和椎骨水平的影响。重复测量的效果用ANOVA评估。用U Mann-Whitney检验分析冻融循环之间的差异（P≤0.05）。结果F组在无轴向负荷的情况下表现出365 mbar的椎间盘内压，C1组为473 mbar，C2组为391 mbar。在400N轴向载荷下，F组的椎间盘内压力为10610 mbar，C1组的椎间盘内压力为10132 mbar，C2组的椎间盘内压力为12074 mbar。统计分析显示了猪标本的显着影响（p结论）结果表明，冻融循环可能会影响标本内压力的测量，并且标本间存在很大差异。在体外生物力学测试中，使用同一标本作为其自身的对照可以推荐。

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