Present study efforts are focusing to develop the flurbiprofen fast dissolving tablets using sublimation method to enhance the dissolution rate. In this study an attempt was made to fasten the drug release from the oral tablets by incorporating the sublimating agents in the presence of crosspovidone as superdisintegrant and studied the effect on dissolution rate when compared to conventional tablets. In the present study, sublimated fast dissolving tablets were prepared by direct compression method. The prepared tablets were characterized for physical parameters and drug release behavior and the best formulation was subjected to pharmacokinetic studies. From in vitro drug release studies, the formulation F2 showed fast drug release of about 99.94±0.26% in 30 min, and disintegration time 34.42 ± 0.74 sec. The percent drug release in 15 min (Q_(15)) and initial dissolution rate for formulation F2 was 91.46±1.42%, 6.10%/min. The dissolution efficiency was found to be 53.44 and it is increased by 4.5 fold with F2 sublimated tablets. From the pharmacokinetic evaluation, the conventional tablets producing peak plasma concentration (C_(max)) was 9023.68±561.83 ng/ml at 3 h T_(max) and F2 sublimated tablets showed C_(max) 11126.71±123.56 ng/ml at 2 h T_(max). The area under the curve for the conventional and F2 tablets was 30968.42±541.52 and 42973.66±568.13 ng h/ml. Hence, the development of flurbiprofen fast dissolving tablets by sublimation method is a right way to enhance not only the dissolution rate but also the absorption rate.
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机译：当前的研究工作集中于使用升华方法开发氟比洛芬快速溶解片剂以提高溶解速率。在这项研究中，人们试图通过在交联维酮作为超级崩解剂的情况下加入升华剂来固定从口服片剂中释放的药物，并研究了与常规片剂相比对溶出度的影响。在本研究中，通过直接压片法制备了升华的快速溶解片剂。对制备的片剂的物理参数和药物释放行为进行表征，并对最佳制剂进行药代动力学研究。根据体外药物释放研究，制剂F2在30分钟内显示出约99.94±0.26％的快速药物释放，崩解时间为34.42±0.74秒。 15分钟内的药物释放百分比（Q_（15））和制剂F2的初始溶出率为91.46±1.42％，6.10％/ min。发现溶解效率为53.44，并且用F2升华的片剂提高了4.5倍。根据药代动力学评估，常规片剂在3 h时产生峰值血浆浓度（C_（max））为9023.68±561.83 ng / ml T_（max），F2升华片在2 h时显示C_（max）11126.71±123.56 ng / ml T_（最大值）。常规片剂和F2片剂的曲线下面积为30968.42±541.52和42973.66±568.13 ng h / ml。因此，通过升华法开发氟比洛芬速溶片不仅是提高溶出率，而且是提高吸收率的正确方法。
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