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Multimodal Frequency Treatment for Facial Pain Caused by Chronic Rhinosinusitis: A Pilot Study

机译：多模式频率治疗慢性鼻-鼻窦炎引起的面部疼痛的初步研究

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Chronic rhinosinusitis (CRS) is a common disease that affects over 200 million patients worldwide. CRS often presents with facial pain, which is considered an important criterion for the diagnosis of CRS. A single-arm clinical study was designed to test the effect of simultaneous high (1 MHz) and low frequencies (70?￠????80 Hz) on facial pain in 14 CRS patients at the Sarah Bush Lincoln Health Center, Mattoon, IL, USA. We used two quality of life (QOL) instruments to test the effect of multimodal frequencies on patients suffering from CRS: the Brief Pain Inventory Short Form (BPI-SF), and the Sino-Nasal Outcome Test (SNOT-22). Mean BPI-SF severity scores improved by 0.80 points (Wilcoxon rank sum test p < 0.01) in all 14 patients. In patients with baseline facial pain ( n = 9), the scores improved by an average of 1.5 ( p < 0.01) points in the pain severity domain and by 1.4 points in the pain interference domain. Additionally, the mean improvement in SNOT-22 scores was 14.11 ( p < 0.05), which is above the minimal clinically-important difference (MCID) of nine points. Our pilot study indicates that multimodal vibration frequencies applied over the facial sinuses reduce pain, possibly through the reduction of the inflammatory response and modulation of the pain receptors. This study suggests the possibility that combining different frequencies could have an enhanced effect on reducing CRS-related facial pain.
机译：慢性鼻-鼻窦炎（CRS）是一种常见疾病，全球范围内影响着超过2亿患者。 CRS常伴有面部疼痛，这被认为是诊断CRS的重要标准。设计了一项单臂临床研究，以测试同时高频率（1 MHz）和低频率（70 ??????? 80 Hz）对14位CRS患者的面部疼痛的影响，该患者位于Mattoon，Sarah Bush Lincoln Health Center，美国伊利诺伊州。我们使用两种生活质量（QOL）仪器来测试多模式频率对CRS患者的影响：简短疼痛库存简短表（BPI-SF）和鼻-鼻窦结局测试（SNOT-22）。所有14例患者的平均BPI-SF严重程度评分均提高了0.80分（Wilcoxon等级和检验p <0.01）。在基线面部疼痛患者中（n = 9），在疼痛严重程度域中的得分平均提高了1.5分（p <0.01），在疼痛干扰域中的得分提高了1.4分。此外，SNOT-22评分的平均改善为14.11（p <0.05），高于9分的最小临床重要差异（MCID）。我们的初步研究表明，施加在面部鼻窦上的多峰振动频率可以减轻疼痛，可能是通过减少炎症反应和调节疼痛感受器来实现的。这项研究表明，组合不同频率可以减轻CRS相关的面部疼痛。

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