• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Sinusitis >Complications of Short-Course Oral Corticosteroids for Eosinophilic Chronic Rhinosinusitis during Long-Term Follow-Up
【24h】

Complications of Short-Course Oral Corticosteroids for Eosinophilic Chronic Rhinosinusitis during Long-Term Follow-Up

机译：长期随访期间，短程口服皮质类固醇治疗嗜酸性慢性鼻窦炎的并发症

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The literature strongly recommends the use of oral corticosteroids in the management of patients with eosinophilic chronic rhinosinusitis (CRS) with nasal polyps. Although potential complications associated with the long-term use of oral corticosteroids for the treatment of CRS have been suggested, no studies have described these effects in detail. Forty-three patients with a mean age of 51 years with eosinophilic CRS were retrospectively evaluated after surgery. Short-course oral prednisolone (PSL, 0.5 mg/kg of body weight) was provided for one week when anosmia and eosinophilic mucin and/or nasal polyps were present. The postoperative follow-up period ranged from 12 to 108 months (average: 62 months). HbA1C showed normal ranges in all except one patient, who had a diabetic pattern of HbA1C of 6.5%. Five patients had serum cortisol levels below the cutoff value. However, re-examination of the serum cortisol and adrenocorticotropic hormone stimulation test showed normal ranges in all five patients who had initially shown abnormal values of serum cortisol. Thus, adrenal insufficiency in all the patients was negligible. Five (3 women and 2 men) out of the 15 patients (6 women and 9 men) who participated in bone mineral density measurement showed significant reductions, suggesting the presence of osteoporosis. Patients taking long-term and repeated short-course use of oral corticosteroids for refractory nasal polyps of eosinophilic CRS are likely to have a potentially increased risk for osteoporosis.
机译：文献强烈建议在患有鼻息肉的嗜酸性慢性鼻鼻窦炎（CRS）患者的治疗中使用口服糖皮质激素。尽管已建议长期使用口服糖皮质激素治疗CRS相关的潜在并发症，但尚无研究详细描述这些作用。回顾性分析了43例平均年龄为51岁的嗜酸性CRS患者。当存在失眠症和嗜酸性粘蛋白和/或鼻息肉时，给予短疗程口服泼尼松龙（PSL，0.5 mg / kg体重）一周。术后随访时间为12至108个月（平均62个月）。 HbA1C在所有患者中均显示正常范围，只有一名患者的糖尿病模式为6.5％。五名患者的血清皮质醇水平低于临界值。然而，重新检查血清皮质醇和促肾上腺皮质激素刺激试验显示，在最初显示出血清皮质醇异常值的所有五位患者中，其正常范围。因此，所有患者的肾上腺功能不全可以忽略不计。参加骨矿物质密度测量的15例患者（6例女性和9例男性）中有5例（3例女性和2例男性）表现出明显的降低，表明存在骨质疏松症。长期和反复短期使用口服皮质类固醇治疗嗜酸性CRS难治性鼻息肉的患者可能会增加骨质疏松症的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号