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首页> 外文期刊>South African medical journal = >An increase in rates of obstetric haemorrhage in a setting of high HIV seroprevalence
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An increase in rates of obstetric haemorrhage in a setting of high HIV seroprevalence

机译：在艾滋病毒血清高流行的情况下，产科出血率增加

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BACKGROUND. Obstetric haemorrhage (OH) is the leading cause of maternal mortality worldwide, although, indirectly, HIV is also a leading cause of maternal mortality in some settings with a high HIV seroprevalence. OBJECTIVE. To determine the possible association between increasing rates of OH and HIV or its treatment. METHODS. We conducted a retrospective chart review of women with OH at King Edward VIII Hospital, Durban, South Africa, over a 3-year period (2009 - 2011), during which the drug regimen for the prevention of mother-to-child transmission was evolving from single-dose nevirapine to antenatal zidovudine combined with intrapartum nevirapine (also referred to as dual therapy), and finally to a combination or highly active antiretroviral therapy (cART or HAART). Cases of OH (including abruptio placentae, placenta praevia, unspecified antepartum haemorrhage (APH), and postpartum haemorrhage (PPH)) were identified from maternity delivery records, and the relevant data extracted. RESULTS. We analysed the records of 448 women diagnosed with OH. Even though the incidence of OH was low, the study found an increasing number of cases during the 3-year period. PPH - not APH - was associated with HIV seropositivity (odds ratio 1.84, 95% confidence interval 1.14 - 2.95). cART was not associated with an increased risk of haemorrhage. CONCLUSION. HIV was associated with a high risk of PPH, and its possible association with HIV treatment needs further research.
机译：背景。产科出血（OH）是全球孕产妇死亡的主要原因，尽管在某些艾滋病毒血清感染率较高的环境中，HIV间接地也是孕产妇死亡的主要原因。目的。确定OH和HIV发生率增加或其治疗之间的可能关联。方法。我们在南非德班国王爱德华八世医院进行了为期3年（2009年至2011年）的患有OH的妇女的回顾性图表审查，在此期间，预防母婴传播的药物方案正在不断发展从单剂量奈韦拉平到产前齐多夫定联合产前奈韦拉平（也称为双重疗法），最后是联合或高效抗逆转录病毒疗法（cART或HAART）。从产妇分娩记录中鉴定出OH病例（包括胎盘早破，胎盘早剥，未明确的产前出血（APH）和产后出血（PPH）），并提取相关数据。结果。我们分析了448名被诊断为OH的女性的记录。即使OH的发生率较低，该研究发现3年期间的病例数也在增加。 PPH（而非APH）与HIV血清阳性有关（赔率1.84，95％置信区间1.14-2.95）。 cART与出血风险增加无关。结论。 HIV与PPH的高风险有关，其与HIV治疗的可能关联需要进一步研究。

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