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首页> 外文期刊>South African Journal of Physiotherapy >The utility of using peak expiratory flow and forced vital capacity to predict poor expiratory cough flow in children with neuromuscular disorders
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The utility of using peak expiratory flow and forced vital capacity to predict poor expiratory cough flow in children with neuromuscular disorders

机译：利用峰值呼气流量和强制肺活量来预测神经肌肉疾病患儿的呼气咳嗽流量不良的效用

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Background: ?Approximately one in every 1200 South Africans is affected by a neuromuscular disease (NMD). Weak respiratory muscles and ineffective cough contribute to the development of respiratory morbidity and mortality. Early identification of individuals at risk of respiratory complications, through peak expiratory cough flow (PCF) measurement, may improve patient outcomes through timely initiation of cough augmentation therapy. Objectives: ?The aim of this study was to investigate the relationship between peak expiratory flow (PEF), forced vital capacity (FVC) and PCF in South African children with neuromuscular disorders. Methods: ?A retrospective descriptive study of routinely collected data was conducted. Results: ?Forty-one participants (aged 11.5 ± 3.6 years; 75.6% male) were included. There was a strong linear correlation between PCF and PEF ( R ?= 0.78;? p = 0.0001) and between PCF and FVC ( R ?= 0.61;? p ?= 0.0001). There was good agreement between PCF and PEF, with intraclass correlation coefficient of 0.8 (95% confidence interval, 0.7–0.9;? p ? 0.0001). Peak expiratory flow 160 L.min ?1 ?and FVC 1.2 L were significantly predictive of PCF 160 L.min ?1 (suggestive of cough ineffectiveness), whilst PEF 250 L.min ?1 ?was predictive of PCF 270 L.min ?1 , the level at which cough assistance is usually implemented. Conclusion: ?PEF and FVC may be surrogate measures of cough effectiveness in children with neuromuscular disorders. Clinical implications: ?PEF and FVC may be considered for clinical use as screening tools to identify patients at risk for pulmonary morbidity related to ineffective cough.
机译：背景：？每1200名南非人中就有大约1名患有神经肌肉疾病（NMD）。呼吸肌无力和咳嗽无效导致呼吸道发病和死亡。通过峰值呼气咳嗽流量（PCF）测量来及早发现有呼吸系统并发症风险的个体，可以通过及时开始咳嗽增强疗法改善患者的预后。目的：这项研究的目的是调查南非神经肌肉疾病患儿的呼气峰流量（PEF），强迫肺活量（FVC）和PCF之间的关系。方法：对常规收集的数据进行回顾性描述性研究。结果：共纳入41名参与者（年龄11.5±3.6岁;男性75.6％）。 PCF和PEF之间（R≤0.78;ρp＝ 0.0001）和PCF与FVC之间有很强的线性相关性（R≥0.61;ρp＝ 0.0001）。 PCF和PEF之间具有良好的一致性，组内相关系数为0.8（95％置信区间为0.7–0.9 ;? p？<0.0001）。峰值呼气流量<160 L.min？1？和FVC <1.2 L显着预测PCF <160 L.min？1（提示咳嗽无效），而PEF <250 L.min？1？则预测PCF < 270 L.min？1，通常是辅助咳嗽的水平。结论：？PEF和FVC可能是神经肌肉疾病患儿咳嗽有效性的替代指标。临床意义：？PEF和FVC可能被认为是临床上的筛查工具，用于识别因无效咳嗽而有患肺病风险的患者。

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