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首页> 外文期刊>Stem Cell Reports >Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate
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Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate

机译：在非人类灵长类动物的大脑中，iPSC衍生的神经细胞自体和同种异体移植的直接比较

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Summary Induced pluripotent stem cells (iPSCs) provide the potential for autologous transplantation using cells derived from a patient’s own cells. However, the immunogenicity of iPSCs or their derivatives has been a matter of controversy, and up to now there has been no direct comparison of autologous and allogeneic transplantation in the brains of humans or nonhuman primates. Here, using nonhuman primates, we found that the autologous transplantation of iPSC-derived neurons elicited only a minimal immune response in the brain. In contrast, the allografts caused an acquired immune response with the activation of microglia (IBA-1+/MHC class II+) and the infiltration of leukocytes (CD45+/CD3+). Consequently, a higher number of dopaminergic neurons survived in the autografts. Our results suggest that the autologous transplantation of iPSC-derived neural cells is advantageous for minimizing the immune response in the brain compared with allogeneic grafts.
机译：总结诱导多能干细胞（iPSC）使用来自患者自身细胞的细胞为自身移植提供了潜力。但是，iPSCs或其衍生物的免疫原性一直是一个有争议的问题，到目前为止，还没有直接比较人或非人灵长类动物的自体和异体移植的比较。在这里，我们使用非人类的灵长类动物，发现iPSC衍生神经元的自体移植仅在大脑中引起最小的免疫反应。相反，同种异体移植引起小胶质细胞活化（IBA-1 + / MHC II +）和白细胞浸润（CD45 + / CD3 +）引起获得性免疫应答。因此，更多的多巴胺能神经元在自体移植物中存活。我们的结果表明，与同种异体移植相比，iPSC衍生的神经细胞的自体移植有利于最小化大脑中的免疫反应。

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