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首页> 外文期刊>Sri Lanka Journal of Psychiatry >Association of family history of bipolar disorder with risk of violence in inpatient mania: a cohort study
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Association of family history of bipolar disorder with risk of violence in inpatient mania: a cohort study

机译：躁狂症家族史与住院躁狂症暴力风险的关联：一项队列研究

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BackgroundEvidence suggests that a positive family history of bipolar affective disorder is associated with response to lithium and the course of the illness, in people suffering from this disorder. This may indicate a subgroup of patients with unique characteristics and treatment responses.AimsTo explore associations between a positive family history of bipolar disorder and the risk of violence, in patients hospitalized for treatment of mania.MethodsAdults receiving inpatient treatment for a manic relapse of bipolar affective disorder, at two tertiary care hospitals in Kandy, Sri Lanka were studied as a cohort. For each participant with a positive family history of bipolar disorder, an age and gender matched adult, also suffering from a manic relapse of bipolar affective disorder but without a family history, was included as a control. A second researcher, who was blind to the participants’ family history, assessed the risk of violence among all participants, at baseline, and at weekly intervals thereafter until discharge, using the historical clinical risk management Scale 20 (HCR-20).ResultsA total of 148 participants were included, with 74 each in the study arm and control arm respectively. Of all participants, 57% were females. Significantly higher rates of unemployment, harmful use of alcohol and absence of confiding relationships were found in participants with a positive family history; they also had a significantly higher mean average HCR-20 scores compared to controls.ConclusionA positive family history of bipolar affective disorder was associated with a higher risk of violence during hospitalization for a manic relapse, as indicated by the mean average HCR-20 scores. A positive family history may be a potential identifier of those at a higher risk of violence in bipolar mania.
机译：背景证据表明，患有双相情感障碍的人的积极家族史与锂的反应和疾病进程有关。这可能表明亚组患者具有独特的特征和治疗反应。目的探讨住院躁狂症患者的双相情感障碍阳性家族史和暴力风险之间的关系。方法成人接受住院治疗的躁郁症躁狂复发的住院治疗。队列研究在斯里兰卡康提的两家三级护理医院进行。对于每位具有双相情感障碍家族史阳性的参与者，作为对照，包括年龄和性别相匹配的成年人，也患有双相情感障碍的躁狂复发但没有家族史。第二名研究人员对参与者的家族史无视，使用历史临床风险管理量表20（HCR-20）在基线和此后每周间隔直至出院之前评估了所有参与者之间的暴力风险。包括148名参与者，其中研究组和对照组分别为74名。在所有参与者中，女性占57％。有积极家族史的参与者发现失业率高，有害饮酒和缺乏交往关系;与对照组相比，他们的平均HCR-20平均得分也明显更高。结论双相情感障碍的阳性家族史与住院期间躁狂复发的暴力风险较高相关，如平均HCR-20得分所示。积极的家族史可能是双相躁狂症中暴力风险较高的人群的潜在识别者。

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