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Early changes in somatosensory function in spinal pain: protocol for a systematic review

机译：脊柱痛中体感功能的早期变化：系统评价方案

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Background Back and neck pain are common conditions that have a high burden of disease. Changes in somatosensory function in the periphery, the spinal cord and the brain have been well documented at the time when these conditions have become chronic. It is unknown, however, how early these changes occur, what the timecourse is of sensory dysfunction and what the specific nature of these changes are in the first 12 weeks after onset of pain. In this paper, we describe the protocol for a systematic review of the literature on somatosensory dysfunction in the first 12 weeks after pain onset. Methods and design We will conduct a comprehensive search for articles indexed in the databases Ovid MEDLINE, Ovid Embase, Ovid PsycINFO and Cochrane Central Register of Controlled Trial (CENTRAL) from their inception to August 2013 that report on any aspect of somatosensory function in acute or subacute neck or back pain. Two independent reviewers will screen studies for eligibility, assess risk of bias and extract relevant data. Results will be tabulated and a narrative synthesis of the results conducted. Discussion Currently, there is a gap in our knowledge about the timing of somatosensory changes in back and neck pain. The systematic review outlined in this protocol aims to address this knowledge gap and inform developments in diagnostic tools and pain mechanism-based treatments. Trial Registration Our protocol has been registered on PROSPERO, CRD42013005113 .
机译：背景技术背部和颈部疼痛是常见的疾病，负担很重。当这些状况变为慢性时，周围器官，脊髓和大脑的体感功能发生了变化。然而，尚不清楚这些改变发生的时间如何，感觉障碍的时程是什么，以及在疼痛发作后的最初12周内这些改变的具体性质是什么。在本文中，我们描述了在疼痛发作后的前12周内对体感功能障碍文献进行系统综述的方案。方法和设计我们将对从Ovid MEDLINE，Ovid Embase，Ovid PsycINFO和Cochrane对照试验中央注册系统（CENTRAL）收录的数据库中进行检索的文章进行全面搜索，这些文章报告了急性或慢性体感功能的任何方面。亚急性颈部或背部疼痛。两名独立的评审员将筛选研究的资格，评估偏倚风险并提取相关数据。将结果列表化，并对结果进行叙述性综合。讨论当前，我们对背部和颈部疼痛的体感变化时机的了解尚不足。该协议中概述的系统综述旨在解决这一知识鸿沟，并为诊断工具和基于疼痛机制的治疗方法的发展提供信息。试用注册我们的协议已在PROSPERO，CRD42013005113上注册。

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