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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Cognitive Decline in Chronic Migraine with Nonsteroid Anti-inflammation Drug Overuse: A Cross-Sectional Study
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Cognitive Decline in Chronic Migraine with Nonsteroid Anti-inflammation Drug Overuse: A Cross-Sectional Study

机译：非甾体类抗炎药过度使用对慢性偏头痛的认知下降：跨领域研究

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Background. Chronic migraine with medication overuse headache (CM-MOH) is the most common type of chronic migraine, and it increases risk of stroke and white matter lesions. These pathologic changes could induce cognitive decline. However, the alteration of cognitive function in CM-MOH patients is not established. Therefore, we took this study to reveal the cognitive performances in CM-MOH. Methods. This cross-sectional study was conducted between December 2015 and January 2017. Patients were divided into CM-MOH, CMwoMOH (chronic migraine without medication overuse), and MO (migraine without aura) groups. Cognitive function was assessed in all cases during interictal periods using Addenbrooke’s Cognitive Examination Test (ACE-R), Trail Making Test A/B (TMT A/B), and Digit Symbol Test (DST). Detailed headache characteristics and evaluation of anxiety, depression, and living and sleep quality were collected. Results. 116 patients were included in this study. There were 21 CM-MOHs, 20 CMwoMOHs, 35 MOs, and 40 controls. Age and education were the independent risk factors of cognitive decline (). After adjusting, the risk of cognitive decline was higher in CM compared with control in ACE-R score and language fluency (). In addition, CM-MOH sufferers were in higher risk of memory and executive dysfunction (). The cognitive function had no difference between CM-MOH and CMwoMOH (). Meanwhile, CM-MOH got significantly higher scores than MO in anxiety and depression, with poorer performances in sleep and life quality ().Conclusion. The risk of cognitive decline increased in chronic migraine patients. Nonsteroid anti-inflammatory drugs overuse had no influence on cognitive performances among chronic migraine sufferers.
机译：背景。慢性偏头痛伴药物过度使用性头痛（CM-MOH）是慢性偏头痛的最常见类型，它增加了中风和白质病变的风险。这些病理变化可能导致认知能力下降。但是，尚未确定CM-MOH患者的认知功能改变。因此，我们通过这项研究揭示了CM-MOH中的认知表现。方法。这项横断面研究于2015年12月至2017年1月进行。患者分为CM-MOH，CMwoMOH（无药物过度使用的慢性偏头痛）和MO（无先兆偏头痛）组。使用Addenbrooke的认知检查测验（ACE-R），追踪制作测验A / B（TMT A / B）和数字符号测验（DST）对所有发作期间的认知功能进行了评估。收集了详细的头痛特征以及对焦虑，抑郁，生活和睡眠质量的评估。结果。该研究包括116例患者。有21个CM-MOH，20个CMwoMOH，35个MO和40个对照。年龄和教育程度是认知能力下降的独立危险因素（）。调整后，与ACE-R得分和语言流利度的对照相比，CM的认知下降风险更高。此外，CM-MOH患者的记忆力和执行功能障碍风险更高。 CM-MOH和CMwoMOH（）之间的认知功能没有差异。同时，CM-MOH在焦虑和抑郁方面的得分明显高于MO，在睡眠和生活质量方面表现较差（）。慢性偏头痛患者认知能力下降的风险增加。非甾体类抗炎药过度使用对慢性偏头痛患者的认知能力没有影响。

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