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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Effect of Moxibustion on HIF-1α and VEGF Levels in Patients with Rheumatoid Arthritis
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Effect of Moxibustion on HIF-1α and VEGF Levels in Patients with Rheumatoid Arthritis

机译：艾灸对类风湿关节炎患者HIF-1α和VEGF水平的影响

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Background. Moxibustion has a therapeutic effect of reducing swelling and relieving pain in patients with rheumatoid arthritis (RA) but its mechanism is uncertain. Objective. To evaluate the effect of moxibustion on serum levels of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in patients with RA and to explore the possible mechanism of moxibustion. Methods. This study involved 46 RA patients who had fulfilled the inclusion criteria and were randomly assigned to a treatment group and a control group in an equal ratio. The control group was treated with methotrexate or leflunomide, while the treatment group received methotrexate or leflunomide and moxibustion at ST 36 (Zusanli), BL 23 (Shenshu), and Ashi points. Patients’ clinical symptoms, RA-associated serum markers, and serum levels of TNF-α, IL-1β, HIF-1α, and VEGF were compared in the two groups before and after intervention. Statistical analysis was performed using SPSS 21.0 statistical software. Results. 37 of 46 RA patients eventually completed the whole treatment course. Compared with the control group, the treatment group significantly improved the clinical symptoms () but with no significant differences in RA-associated serum markers (). There were significant differences in TNF-α and IL-1β among the groups after 8 weeks of treatment (). HIF-1α and VEGF were decreased in the treatment group after therapy (). VEGF was reduced in the control group (), while HIF-1α was not significantly improved (). The reductions of HIF-1α and VEGF in the treatment group were superior to the control group ().Conclusions. Moxibustion enhanced the anti-inflammatory and analgesic effects of conventional medicine and can enhance the effect of conventional medicine, downregulating HIF-1α/VEGF contents to inhibit angiogenesis.
机译：背景。艾灸具有减轻类风湿关节炎（RA）患者肿胀和缓解疼痛的治疗作用，但其机制尚不确定。目的。目的评价艾灸对RA患者血清低氧诱导因子-1α（HIF-1α）和血管内皮生长因子（VEGF）水平的影响，探讨艾灸的可能机制。方法。这项研究纳入了46位符合纳入标准的RA患者，并以相等的比例随机分配到治疗组和对照组。对照组接受甲氨蝶呤或来氟米特治疗，而治疗组分别在ST 36（祖三里），BL 23（神树）和阿施穴位接受甲氨蝶呤或来氟米特和艾灸。比较干预前后两组患者的临床症状，RA相关血清标志物以及血清TNF-α，IL-1β，HIF-1α和VEGF水平。使用SPSS 21.0统计软件进行统计分析。结果。 46名RA患者中有37名最终完成了整个治疗过程。与对照组相比，治疗组显着改善了临床症状（），但RA相关血清标志物无显着差异（）。治疗8周后，各组的TNF-α和IL-1β存在显着差异（）。治疗组治疗后HIF-1α和VEGF降低（图）。对照组中VEGF降低（），而HIF-1α没有明显改善（）。治疗组HIF-1α和VEGF的降低优于对照组。艾灸增强了常规药物的抗炎和镇痛作用，并且可以增强常规药物的作用，下调HIF-1α/ VEGF的含量以抑制血管生成。

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