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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome
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Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome

机译：消除IgG和益生菌联合饮食对偏头痛加肠易激综合征的影响

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Several research studies have revealed that migraine has a solid link with gastrointestinal diseases especially irritable bowel syndrome (IBS). This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel syndrome. A total of 60 patients diagnosed with migraine plus IBS were recruited for the study. IgG antibodies against 266 food varieties were detected by ELISA. Then, the subjects were randomized into three groups for treatment of IgG elimination diet or probiotics or diet combined with probiotics. Migraine symptom, gut function score, medication use, and serum serotonin level were measured at baseline, 7?weeks, and 14?weeks. Improvement of migraine and gut symptom was achieved at a certain time point. Reduced use of over-the-counter- (OTC?) analgesics was seen in all groups. However, use of triptans did not show significant difference. An increased serum serotonin level was seen in subjects treated with elimination diet and elimination diet combined with probiotics. IgG elimination diet combined with probiotics may be beneficial to migraine plus IBS. It may provide new insight by understanding the intricate relationship between migraine and gastrointestinal diseases.
机译：多项研究表明，偏头痛与胃肠道疾病，尤其是肠易激综合症（IBS）有着密切的联系。这项研究旨在研究基于IgG消除与益生菌相结合的饮食对偏头痛加肠易激综合征的治疗潜力。该研究共招募了60名诊断为偏头痛加IBS的患者。 ELISA检测了针对266种食品的IgG抗体。然后，将受试者随机分为三组，以治疗IgG消除饮食或益生菌或益生菌联合饮食。在基线，第7周和第14周时测量偏头痛症状，肠道功能评分，用药情况和血清5-羟色胺水平。在特定时间点偏头痛和肠道症状得到改善。在所有组中都发现减少了非处方镇痛药的使用。但是，曲普坦的使用没有显示出显着差异。在用消除饮食和消除饮食与益生菌联合治疗的受试者中，血清血清素水平升高。消除IgG的饮食和益生菌可能对偏头痛加IBS有益。通过了解偏头痛和胃肠道疾病之间的复杂关系，可以提供新的见解。

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