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首页> 外文期刊>Pain research & management: the journal of the Canadian Pain Society = journal de la socie?te? canadienne pour le traitement de la douleur >Serum Triamcinolone Levels following Cervical Interlaminar Epidural Injection
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Serum Triamcinolone Levels following Cervical Interlaminar Epidural Injection

机译：颈椎间盘硬膜外注射后血清曲安西龙水平

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Background. Cervical interlaminar epidural steroid injections (ESIs) are commonly performed procedures to treat painful cervical radiculopathy, but little is known about the systemic absorption and serum levels of steroids following injection. The primary objective of this study was to investigate the pharmacokinetics of fluoroscopy-guided cervical epidural-administered triamcinolone acetonide in a cohort of patients with cervical radicular pain seeking treatment in a pain medicine clinic. Methods. The study cohort included eight patients undergoing a fluoroscopically guided C7-T1 interlaminar ESI at a pain medicine specialty clinic. Blood was collected prior to the ESI and on days 1, 2, 4, 6, 8, 14, 21, 28, 35, and 42 following the injection. The sample extract was analyzed by tandem mass spectrometry. Results. The terminal elimination half-life of cervical epidural-administered triamcinolone in a noncompartmental analysis was 219 hours. In the noncompartmental analysis, peak triamcinolone concentrations of 5.4?ng/mL were detected within 22.1 hours after administration. Conclusions. The pharmacokinetics of cervical epidural-administered triamcinolone is consistent with our previous study of lumbar ESI, demonstrating that the elimination half-life is longer than that which has been reported following intravenous triamcinolone. The elimination half-life was shorter following cervical ESI than that which has been reported following lumbar ESI.
机译：背景。颈椎层间硬膜外类固醇注射（ESI）是治疗疼痛性颈神经根病的常用方法，但对注射后类固醇的全身吸收和血清水平知之甚少。这项研究的主要目的是研究透视法指导的颈硬膜外注射曲安奈德丙酮酸对在疼痛医学诊所寻求治疗的一系列宫颈放射性疼痛患者的药代动力学。方法。该研究队列包括八名在疼痛医学专科诊所接受透视引导下的C7-T1层间ESI的患者。在ESI之前以及注射后第1、2、4、6、8、14、21、28、35和42天收集血液。通过串联质谱分析样品提取物。结果。在非房室分析中，硬膜外注射曲安西龙的最终消除半衰期为219小时。在非房室分析中，在给药后22.1小时内检测到曲安西龙的峰值浓度为5.4？ng / mL。结论。颈硬膜外给药曲安西龙的药代动力学与我们先前对腰椎ESI的研究一致，表明消除半衰期比静脉注射曲安西龙后报道的更长。颈ESI后的消除半衰期比腰ESI后的消除半衰期短。

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