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首页> 外文期刊>Pain Studies and Treatment >Effects of Extremely Low Frequency Magnetic Field (ELF-MF) on Formalin Induced Chronic Pain in Mice
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Effects of Extremely Low Frequency Magnetic Field (ELF-MF) on Formalin Induced Chronic Pain in Mice

机译：极低频磁场（ELF-MF）对福尔马林诱导的小鼠慢性疼痛的影响

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Background: Effects of Extremely Low Frequency Magnetic Field) ELF-MF (in the elevation of blood sugar, cholesterol, triglyceride and reduction of withdrawal syndrome of morphine have been reported so far. Since pain is one of the main concerns in medicine and usually analgesic drugs are not much beneficial or cause considerable side effects, the present project was carried out with the aim of evaluating the effects of (ELF-MF (in chronic pain using formalin test in mice. Materials & Methods: In this experimental study, thirty two adult male mice were used and divided into 4 groups (n = 8). Three groups of animals exposed daily for thirty minutes to 25, 50, 75 HZ (intense 250 μT) of electromagnet field for one week, respectively and one group considered as control with no exposure. At the end of a week, formalin test was performed. Responses to formalin were observed for sixty minutes. The results were compared between tests and control group. Findings: In acute phase of formalin test, ELF-MF reduced significantly the pain scores following formalin injection at all 3 frequencies, especially at 25 and 50 HZ (p < 0.001) rather 75 HZ (p < 0.05). In chronic phase of formalin test, ELF-MF reduced pain scores at 25 and 50 HZ (p < 0.05). However, the most effective responses were obtained at 50 HZ frequency. Conclusion: The findings show that ELF-MF is effective to reduce formalin induced chronic pain in mice at both acute and chronic phases.
机译：背景：极低频磁场的作用迄今为止，已经报道了ELF-MF（在血糖，胆固醇，甘油三酸酯升高和吗啡戒断综合征减轻方面），因为疼痛是医学上的主要问题之一，通常是止痛药药物效果不佳或不会引起明显的副作用，本项目旨在评估（ELF-MF（在慢性疼痛中使用福尔马林测试对小鼠的影响）。材料与方法：在本实验研究中，32使用成年雄性小鼠，分为4组（n = 8），三组动物分别每天在25、50、75 HZ（强度250μT）的电磁场中暴露30分钟，持续一周，而另一组视为对照组：无接触;一周结束后，进行福尔马林测试;观察对福尔马林的反应，持续60分钟;结果与对照组和对照组进行比较。 ELF-MF在所有3个频率下都显着降低了福尔马林注射后的疼痛评分，尤其是在25和50 HZ（p <0.001）而非75 HZ（p <0.05）时。在福尔马林测试的慢性阶段，ELF-MF降低了25和50 HZ时的疼痛评分（p <0.05）。但是，最有效的响应是在50 HZ频率下获得的。结论：研究结果表明，ELF-MF可有效减轻福尔马林在急性期和慢性期引起的小鼠慢性疼痛。

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