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首页> 外文期刊>Pathology Research International >Clear Cell Carcinomas of the Mullerian System: Does the Pathogenesis Vary Depending on Their Nuclear Grade and Their Association with Endometriosis? An Immunohistochemical Analysis
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Clear Cell Carcinomas of the Mullerian System: Does the Pathogenesis Vary Depending on Their Nuclear Grade and Their Association with Endometriosis? An Immunohistochemical Analysis

机译：苗勒氏系统的透明细胞癌：发病机理是否取决于其核分级及其与子宫内膜异位的关联？免疫组织化学分析

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Clear cell carcinomas (CCC) of the mullerian system are considered high grade tumors, but morphologically, the cells of CCC show both low and high grade features. The aims of the current study were to categorize CCC into low and high nuclear grade types, correlate their association with endometriosis, and then observe possible variations in pathogenesis based on their expression of p53 and Ki-67. We studied 41 pure mullerian CCCs and designated each as either a high (HNG) or low (LNG) nuclear grade tumor. Morphologically, 17 (41%) CCCs were LNG and 24 (59%) were HNG. Nine (38%) HNG and 2 (12%) LNG tumors showed positive immunostaining with p53. Endometriosis was associated with 8 (47%) LNG tumors and 8 (33%) HNG CCCs. Of the 11 cases with p53 alteration, 4 (1 LNG and 3 HNG) were associated with endometriosis. Conclusions: HNG CCCs, irrespective of their association with endometriosis, have alterations of p53. In general, LNG ovarian and endometrial CCCs, irrespective of their association with endometriosis/adenomyosis, are less likely to show p53 alteration. It appears that mullerian CCCs may have variable pathogenesis depending on their nuclear grade and association with endometriosis. A larger study is needed to validate these findings.
机译：苗勒氏系统的透明细胞癌（CCC）被认为是高等级的肿瘤，但是从形态上讲，CCC的细胞同时具有低等级和高等级特征。当前研究的目的是将CCC分为低核级和高核级类型，将其与子宫内膜异位症相关联，然后根据其p53和Ki-67的表达观察发病机理的可能变化。我们研究了41种纯苗勒氏CCC，并将其分别指定为高（HNG）或低（LNG）核级肿瘤。从形态上讲，17个（41％）CCC为液化天然气，而24个（59％）为HNG。 9例（38％）HNG和2例（12％）LNG肿瘤显示p53免疫阳性。子宫内膜异位症与8个（47％）LNG肿瘤和8个（33％）HNG CCC相关。在11例p53改变的病例中，有4例（1 LNG和3 HNG）与子宫内膜异位相关。结论：HNG CCC，无论其与子宫内膜异位症的关联如何，均具有p53的改变。通常，LNG卵巢和子宫内膜CCC，无论其与子宫内膜异位/子宫腺肌病的关联如何，都不太可能显示p53改变。苗勒氏CCC似乎具有可变的发病机制，这取决于它们的核级和与子宫内膜异位的关联。需要进行更大的研究才能验证这些发现。

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