...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Patient Preference and Adherence >Difficult to swallow: patient preferences for alternative valproate pharmaceutical formulations
【24h】

Difficult to swallow: patient preferences for alternative valproate pharmaceutical formulations

机译：难以吞咽：患者对丙戊酸替代药物制剂的偏好

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To determine the degree to which swallowing valproate (VP) tablets is an issue, the proportion of patients who would prefer an alternative formulation, and the predictors of preference.Methods: A quantitative telephone survey of eligible adults (n = 400, ≥18 years old) who currently take (n = 236) or previously took (n = 164) VP tablets within the past 6 months was conducted.Results: More than half of the patients indicated that VP tablets were ‘uncomfortable to swallow’ (68.5%, n = 274) and were ‘very interested’ (65.8%, n = 263) in medications that were easier to swallow. When choosing conceptually between taking VP tablet once/day or an equally safe and effective but significantly smaller soft gel capsule twice per day, the 82.8%, (n = 331) preferred the soft gel capsule. In the multivariate regression analysis, perceiving soft gel capsules to be easier to swallow (OR = 73.54; 95% CI = 15.01 to 360.40) and taking VP more frequently (OR = 2.02; 95% CI = 1.13 to 3.61) were significant predictors of soft gel capsule treatment preference.Conclusion: VP users would prefer a formulation that is easier to swallow, even if it is needed to be taken twice per day. When choosing between medications with similar efficacy and safety, physicians can consider patient preferences to optimize conditions for medication adherence.
机译：目的：确定服用丙戊酸盐（VP）片剂的程度，愿意使用替代制剂的患者比例以及偏好的预测因素。方法：对合格成年人（n = 400，≥结果：超过半数的患者表示VP片剂“不易吞咽”（68.5岁）（目前18岁）在过去6个月内正在服用（n = 236）或以前服用（n = 164）VP片剂。 ％，n = 274），并且对容易吞咽的药物“非常感兴趣”（65.8％，n = 263）。从概念上选择每天一次服用VP片剂还是每天两次安全有效但明显更小的软胶囊，两者之间的选择在概念上是82.8％（n = 331）的人首选软胶囊。在多元回归分析中，认为软胶囊容易吞咽（OR = 73.54; 95％CI = 15.01至360.40）和更频繁地服用VP（OR = 2.02; 95％CI = 1.13至3.61）是以下因素的重要预测指标结论：VP使用者更喜欢吞咽较容易的制剂，即使需要每天服用两次。在疗效和安全性相似的药物之间进行选择时，医生可以考虑患者的喜好，以优化药物依从性的条件。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号