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Varenicline for smoking cessation: efficacy, safety, and treatment recommendations

机译:Varenicline戒烟:疗效,安全性和治疗建议

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Abstract: Smoking is the leading preventable cause of morbidity and mortality in the US, and decreasing smoking prevalence is a public health priority. Patients achieve the greatest success when quit attempts involve behavioral therapy combined with pharmacotherapy. Varenicline is the most recent addition to the pharmacotherapeutic armamentarium for the treatment of tobacco dependence. Varenicline is efficacious and cost-effective. Smoking relapse and adverse treatment-related side effects may decrease medication adherence and patient satisfaction with varenicline. In the clinical setting, varenicline treatment can be optimized by reducing doses in patients who experience intolerable side effects, increasing the dose in partial responders, and providing long-term maintenance therapy for relapse prevention.
机译:摘要:吸烟是美国发病率和死亡率的主要可预防原因,降低吸烟率是公共卫生的重中之重。当戒烟尝试涉及行为疗法与药物疗法相结合时,患者将获得最大的成功。瓦伦尼克林是药物治疗药库中最新的药物,可用于治疗烟草依赖。瓦伦尼克林有效且具有成本效益。吸烟复发和与治疗相关的不良副作用可能会降低药物依从性和患者对伐尼克兰的满意度。在临床环境中,伐尼克兰治疗可以通过减少出现无法忍受的副作用的患者的剂量,增加部分缓解者的剂量以及为预防复发提供长期维持治疗来优化。

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