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首页> 外文期刊>Patient Preference and Adherence >Estimation of EuroQol 5-Dimensions health status utility values in hereditary angioedema
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Estimation of EuroQol 5-Dimensions health status utility values in hereditary angioedema

机译：遗传性血管性水肿中EuroQol 5维健康状况效用值的估计

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Objective: To estimate health status utility (preference) weights for hereditary angioedema (HAE) during an attack and between attacks using data from the Hereditary Angioedema Burden of Illness Study in Europe (HAE-BOIS-Europe) survey. Utility measures quantitatively describe the net impact of a condition on a patient’s life; a score of 0.0 reflects death and 1.0 reflects full health. Study design and methods: The HAE-BOIS-Europe was a cross-sectional survey conducted in Spain, Germany, and Denmark to assess the real-world experience of HAE from the patient perspective. Survey items that overlapped conceptually with the EuroQol 5-Dimensions (EQ-5D) domains (pain/discomfort, mobility, self-care, usual activities, and anxiety/depression) were manually crosswalked to the corresponding UK population-based EQ-5D utility weights. EQ-5D utilities were computed for each respondent in the HAE-BOIS-Europe survey for acute attacks and between attacks. Results: Overall, a total of 111 HAE-BOIS-Europe participants completed all selected survey items and thus allowed for computation of EQ-5D-based utilities. The mean utilities for an HAE attack and between attacks were 0.44 and 0.72, respectively. Utilities for an acute attack were dependent on the severity of pain of the last attack (0.61 for no pain or mild pain, 0.47 for moderate pain, and 0.08 for severe pain). There were no significant differences across countries. Mean utilities derived from the study approach compare sensibly with other disease states for both acute attacks and between attacks. Conclusion: The impacts of HAE translate into substantial health status disutilities associated with acute attacks as well as between attacks, documenting that the detrimental effects of HAE are meaningful from the patient perspective. Results were consistent across countries with regard to pain severity and in comparison to similar disease states. The results can be used to raise awareness of HAE as a serious disease with wide-ranging personal and social impacts.
机译：目的：使用欧洲疾病研究的遗传性血管性水肿负担（HAE-BOIS-Europe）调查数据，估算发作期间和发作之间的遗传性血管性水肿（HAE）的健康状况效用（偏好）权重。效用度量定量地描述了疾病对患者生命的净影响;得分0.0代表死亡，得分1.0代表健康。研究设计和方法：HAE-BOIS-Europe是一项在西班牙，德国和丹麦进行的横断面调查，旨在从患者的角度评估HAE的真实经验。在概念上与EuroQol 5维（EQ-5D）域（疼痛/不适，移动性，自我护理，日常活动以及焦虑/抑郁）重叠的调查项目被手动横穿到相应的英国基于人群的EQ-5D实用程序中重量。在HAE-BOIS-Europe欧洲调查中针对急性发作和两次发作之间的每个响应者，计算了EQ-5D效用。结果：总体上，共有111名HAE-BOIS-Europe参与者完成了所有选定的调查项目，因此可以计算基于EQ-5D的效用。 HAE攻击和两次攻击之间的平均效用分别为0.44和0.72。急性发作的实用性取决于上次发作的疼痛严重程度（无疼痛或轻度疼痛为0.61，中度疼痛为0.47，重度疼痛为0.08）。各国之间没有显着差异。从研究方法中得出的平均效用在急性发作和发作之间都可以合理地与其他疾病状态进行比较。结论：HAE的影响转化为与急性发作以及发作之间有关的严重的健康状况损害，证明了HAE的有害作用从患者角度来看是有意义的。各国在疼痛严重程度方面以及与类似疾病状态相比，结果都是一致的。该结果可用于提高人们对HAE的认识，因为它是一种严重的个人和社会影响严重的疾病。

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