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首页> 外文期刊>Patient Preference and Adherence >Adverse events and patients’ perceived health-related quality of life at the end of multidrug-resistant tuberculosis treatment in Namibia
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Adverse events and patients’ perceived health-related quality of life at the end of multidrug-resistant tuberculosis treatment in Namibia

机译：纳米比亚耐多药结核病治疗结束后的不良事件和患者与健康相关的生活质量

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Purpose: The health-related quality of life (HRQoL) of patients completing multidrug-resistant tuberculosis (MDR-TB) treatment in Namibia and whether the occur-rence of adverse events influenced patients’ rating of their HRQoL was evaluated. Patients and methods: A cross-sectional analytic survey of patients completing or who recently completed MDR-TB treatment was conducted. The patients rated their HRQoL using the simplified Short Form-8? (SF-8) questionnaire consisting of eight Likert-type questions. Three supplemental questions on the adverse events that the patients may have experienced during their MDR-TB treatment were also included. Scoring of HRQoL ratings was norm-based (mean =50, standard deviation =10) ranging from 20 (worst health) to 80 (best health), rather than the conventional 0–100 scores. We evaluated the internal consistency of the scale items using the Cronbach’s alpha, performed descriptive analyses, and analyzed the association between the patients’ HRQoL scores and adverse events. Results: Overall, 36 patients (20 males, 56%) aged 17–54?years (median =40?years) responded to the questionnaire. The median (range) HRQoL score for the physical component summary was 58.6 (35.3–60.5), while the median score for the mental component summary was 59.3 (26.6–61.9), indicating not-so-high self-rating of health. There was good internal consistency of the scale scores, with a Cronbach’s alpha value of >0.80. In all, 32 (89%) of the 36 patients experienced at least one adverse drug event of any severity during their treatment (median events =3, range 1–6), of which none was life-threatening. The occurrence of adverse events was not related to HRQoL scores. For patients reporting zero to two events, the median (range) HRQoL score was 56.8 (44.4–56.8), while for those reporting three or more events, the median score was 55.2 (38.6–56.8); P =0.34 for difference between these scores. Conclusion: Patients completing treatment for MDR-TB in Namibia tended to score moderately low on their HRQoL, using the generic SF-8 questionnaire. The occurrence of adverse events did not lead to lower HRQoL scores upon treatment completion.
机译：目的：评估纳米比亚完成耐多药结核病（MDR-TB）治疗的患者的健康相关生活质量（HRQoL），以及不良事件的发生是否会影响患者对其HRQoL的评分。患者和方法：对完成或最近完成耐多药结核病治疗的患者进行横断面分析调查。患者使用简化的Short Form-8对他们的HRQoL进行评分。 （SF-8）问卷由八个李克特型问题组成。还包括三个有关患者在耐多药结核病治疗期间可能经历的不良事件的补充问题。 HRQoL评分的得分是基于标准的（平均值= 50，标准差= 10），范围从20（最差健康）到80（最佳健康），而不是传统的0-100评分。我们使用Cronbach's alpha评估了量表项目的内部一致性，进行了描述性分析，并分析了患者的HRQoL得分与不良事件之间的关联。结果：总体上，有36例患者（20名男性，占56％）年龄在17-54岁（中位数= 40岁），对问卷进行了回答。身体成分摘要的HRQoL中位数（范围）为58.6（35.3-60.5），而精神成分摘要的中值（范围）为59.3（26.6-61.9），表明健康的自我评价不那么高。量表分数具有良好的内部一致性，Cronbach的alpha值> 0.80。在36例患者中，共有32例（89％）在治疗过程中经历了至少一种严重程度的药物不良事件（中位事件= 3，范围为1-6），其中没有一例危及生命。不良事件的发生与HRQoL评分无关。报告零至两次事件的患者，HRQoL评分中位数（范围）为56.8（44.4-56.8），报告三个或更多事件的患者，中位数HRQoL评分为55.2（38.6-56.8）。对于这些得分之间的差异，P = 0.34。结论：使用通用的SF-8调查表，完成纳米比亚MDR-TB治疗的患者的HRQoL得分中等偏低。不良事件的发生并没有导致治疗完成后HRQoL评分降低。

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