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Burden and Management of Multidrug-Resistant Organisms in Palliative Care

机译:姑息治疗中耐多药生物的负担和管理

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Palliative care includes comprehensive strategies to optimize quality of life for patients and families confronting terminal illness. Infections are a common complication in terminal illness, and infections due to multidrug-resistant organisms (MDROs) are particularly challenging to manage in palliative care. Limited data suggest that palliative care patients often harbor MDRO. When MDROs are present, distinguishing colonization from infection is challenging due to cognitive impairment or metastatic disease limiting symptom assessment and the lack of common signs of infection. Multidrug-resistant organisms also add psychological burden through infection prevention measures including patient isolation and contact precautions which conflict with the goals of palliation. Moreover, if antimicrobial therapy is indicated per goals of care discussions, available treatment options are often limited, invasive, expensive, or associated with adverse effects that burden patients and families. These issues raise important ethical considerations for managing and containing MDROs in the palliative care setting.
机译:姑息治疗包括综合策略,以优化面临绝症的患者和家庭的生活质量。感染是绝症中的常见并发症,而由多药耐药生物(MDRO)引起的感染在姑息治疗中尤其具有挑战性。有限的数据表明,姑息治疗患者通常会携带MDRO。当存在MDRO时,由于认知障碍或转移性疾病会限制症状评估,并且缺乏常见的感染征兆,因此很难将定植与感染区分开来。多药耐药生物还通过预防感染措施增加了心理负担,这些措施包括与隔离目标冲突的患者隔离和接触预防措施。此外,如果按照护理讨论的目标指示进行抗微生物治疗,则可用的治疗方案通常是有限的,有创的,昂贵的,或与给患者和家庭带来负担的不良反应相关。这些问题引起了在姑息治疗环境中管理和遏制MDRO的重要伦理考虑。

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