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首页> 外文期刊>Patient Preference and Adherence >Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants: a cross-sectional study
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Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants: a cross-sectional study

机译：华法林和直接口服抗凝药患者之间生活质量和治疗满意度的比较：一项横断面研究

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Introduction and aim: Patient quality of life (QOL) while on long-term oral anticoagulant therapy has been receiving greater attention in recent years due to the increase in life expectancy brought about by advances in medical care. This study aimed to compare the QOL, treatment satisfaction, hospitalization and bleeding rate in patients on long-term warfarin versus direct oral anticoagulants (DOAC). Methods: This was a cross-sectional study of patients with non-valvular atrial fibrillation (NVAF) or venous thromboembolism (VTE) on long-term anticoagulant therapy attending the cardiology clinic and anticoagulation clinic of the University Malaya Medical Centre from July 1, 2016, to June 30, 2018. Patient QOL was assessed by using the Short Form 12 Health Survey (SF12), while treatment satisfaction was assessed by using the Perception of Anticoagulation Treatment Questionnaire 2 (PACT-Q2). Results: A total of 208 patients were recruited; 52.4% received warfarin and 47.6% received DOAC. There was no significant difference in QOL between warfarin and DOAC based on SF12 (physical QOL, P =0.083; mental QOL, P =0.665). Nevertheless, patients in the DOAC group were significantly more satisfied with their treatment compared to the warfarin group based on PACT-Q2 ( P =0.004). The hospitalisation rate was significantly higher in the warfarin group than the DOAC group (15.6% versus 3.0%, P =0.002). Clinically relevant minor bleeds and severe bleeding events were non-significantly higher in the warfarin group than the DOAC group (66.7% versus 40.0%, P =0.069). Conclusion: Compared to warfarin, treatment of NVAF and VTE with DOAC showed comparable QOL, higher treatment satisfaction, lesser hospitalization, and a non-significant trend toward fewer bleeding episodes.
机译：简介和目的：由于医疗保健的进步带来的预期寿命的增加，长期口服抗凝治疗期间的患者生活质量（QOL）受到了越来越多的关注。这项研究旨在比较长期服用华法林与直接口服抗凝剂（DOAC）的患者的生活质量，治疗满意度，住院率和出血率。方法：这是一项对2016年7月1日开始就诊的非瓣膜性房颤（NVAF）或静脉血栓栓塞症（VTE）接受长期抗凝治疗的患者的横断面研究，至2018年6月30日。通过使用简短表格12健康调查（SF12）评估患者的生活质量，而使用抗凝治疗问卷2（PACT-Q2）评估治疗满意度。结果：共招募208例患者。 52.4％的患者接受了华法林，47.6％的患者接受了DOAC。华法林和DOAC的SF12的QOL差异均无统计学意义（物理QOL，P = 0.083;精神QOL，P = 0.665）。尽管如此，与基于PACT-Q2的华法林组相比，DOAC组的患者对治疗的满意度明显更高（P = 0.004）。华法林组的住院率显着高于DOAC组（15.6％对3.0％，P = 0.002）。华法林组的临床相关轻度出血和严重出血事件无统计学意义，高于DOAC组（66.7％对40.0％，P = 0.069）。结论：与华法林相比，DOAC治疗NVAF和VTE表现出可比的QOL，更高的治疗满意度，更少的住院治疗以及出血次数更少的非显着趋势。

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