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首页> 外文期刊>Patient Preference and Adherence >Social anxiety disorder: radio electric asymmetric conveyor brain stimulation versus sertraline
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Social anxiety disorder: radio electric asymmetric conveyor brain stimulation versus sertraline

机译：社交焦虑症：无线电不对称输送带对大脑的刺激与舍曲林的关系

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Purpose: Social anxiety disorder (SAD) is a disabling condition that affects almost 5% of the general population. Many types of drugs have shown their efficacy in the treatment of SAD. There are also some data regarding psychotherapies, but no data are available today about the efficacy of brain stimulation techniques. The aim of the study is to compare the efficacy of noninvasive brain stimulation neuro psycho physical optimization (NPPO) protocol performed by radio electric asymmetric conveyor (REAC) with that of sertraline in adults with SAD.Patients and methods: Twenty SAD patients on sertraline were compared with 23 SAD patients who refused any drug treatment and who chose to be treated with NPPO-REAC brain stimulation. This was a 6-month, open-label, naturalistic study. Patients on sertraline received flexible doses, whereas NPPO-REAC patients received two 18-session cycles of treatment. Clinical Global Improvement scale items "much improved" or "very much improved" and Liebowitz Social Anxiety Scale total score variation on fear and avoidance components were used to detect the results. The statistical analysis was performed with t-test. All measures <0.05 have been considered statistically significant.Results: Ten of 23 subjects on NPPO-REAC and six of the 20 taking sertraline were much improved or very much improved 1 month after the first NPPO-REAC cycle (t1). Sixteen of the subjects on NPPO-REAC and ten of the subjects taking sertraline were much improved or very much improved 1 month after the second NPPO-REAC cycle (t2). In respect of the Liebowitz Social Anxiety Scale, at t1 NPPO-REAC resulted in statistically more efficacy for sertraline on both fear and avoidance total scores. At t2, NPPO-REAC resulted in statistically more efficacy for sertraline on fear but not on avoidance.Conclusion: NPPO-REAC is an effective treatment for SAD, allowing substantial and clinically meaningful reductions in symptoms and disability in comparison with sertraline.
机译：目的：社交焦虑症（SAD）是一种致残性疾病，几乎影响了总人口的5％。许多类型的药物已显示出其在SAD治疗中的功效。也有一些有关心理治疗的数据，但是今天没有关于脑刺激技术功效的数据。这项研究的目的是比较无线电不对称传送带（REAC）与舍曲林对成年SAD的无创性脑刺激神经心理物理优化（NPPO）方案的疗效。患者和方法：20例接受舍曲林的SAD患者相比之下，有23名SAD患者拒绝接受任何药物治疗并选择接受NPPO-REAC脑刺激治疗。这是一个为期6个月的开放式自然主义研究。服用舍曲林的患者接受灵活剂量，而NPPO-REAC患者接受两个18个疗程的治疗。临床全球改善量表项目“大大改善”或“非常改善”，并使用利勃维茨社交焦虑量表的恐惧和回避成分总分变异来检测结果。用t检验进行统计分析。结果：在第一个NPPO-REAC周期（t1）1个月后，NPPO-REAC的23名受试者中有10名和服用舍曲林的20名受试者中有6名得到了很大改善或大大改善。在第二个NPPO-REAC周期（t2）后1个月，接受NPPO-REAC的受试者中有16名和服用舍曲林的受试者有10名得到了很大的改善。就利勃维茨社交焦虑量表而言，NPPO-REAC在t1时在恐惧和回避总分上均显示舍曲林的疗效更高。在第2天时，NPPO-REAC在恐惧上可提高舍曲林的疗效，但不能避免。结论：NPPO-REAC是SAD的有效治疗方法，与舍曲林相比，可以显着且临床上有效地减轻症状和残疾。

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