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首页> 外文期刊>Patient Preference and Adherence >Effectiveness and medication acceptance of olanzapine disintegrating tablets compared to standard olanzapine tablets in acutely treated psychiatric patients
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Effectiveness and medication acceptance of olanzapine disintegrating tablets compared to standard olanzapine tablets in acutely treated psychiatric patients

机译：奥氮平崩解片与标准奥氮平片在急性精神病患者中的疗效和药物接受

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Background: This study compared effectiveness and acceptance of orally disintegrating olanzapine tablets (ODT) with standard-coated tablets (SOT) in acutely ill psychiatric patients admitted to psychiatric hospitals for emergency treatment.Methods: Large, prospective, observational study at hospital emergency units across Germany in patients with a diagnosis or tentative diagnosis of acute schizophrenia treated with ODT or SOT. Clinical (CGI-S and CGI-I) outcomes, attitudes towards medication (Nursing Assessment of Medication Acceptance, NAMA) scale, suicidal ideation, and adverse events were assessed at start of treatment and after 2 weeks.Results: Both olanzapine formulations, ODT (N = 247) and SOT (N = 207), showed similar effectiveness after 2 weeks. CGI-I improved in 92.1% of patients (ODT: 91.8%, SOT: 92.3%). In patients receiving both formulations suicidal ideations were reduced (ODT from 53.9% to 20.6%, SOT from 51.2% to 22.7%). ODT was preferably given to severely ill (SOT: 49.8%, ODT: 64.4%) and aggressive patients. Adverse events were reported for 6.5% of ODT- and 2.9% of SOT-patients. This difference was possibly caused by the characteristics of patients receiving ODT.Conclusions: This non-randomized, observational study shows comparable outcomes and tolerability in patients treated with both olanzapine formulations. In an acute treatment setting, orally disintegrating tablets were preferably used for more severely ill and aggressive patients with low medication acceptance.
机译：背景：本研究比较了口服崩解性奥氮平片（ODT）与标准包衣片（SOT）在接受精神病医院急诊治疗的急性精神病患者中的有效性和接受性。方法：在整个医院急诊室进行的大型前瞻性观察性研究在诊断或初步诊断为急性精神分裂症的患者中，用ODT或SOT治疗。在治疗开始时和2周后评估临床（CGI-S和CGI-I）结果，对药物的态度（护理接受药物评估，NAMA）量表，自杀意念和不良事件。结果：奥氮平制剂，ODT （N = 247）和SOT（N = 207），在2周后显示出相似的疗效。 92.1％的患者的CGI-I改善（ODT：91.8％，SOT：92.3％）。在接受两种配方的患者中，其自杀意识都降低了（ODT从53.9％降低到20.6％，SOT从51.2％降低到22.7％）。 ODT优选用于重症患者（SOT：49.8％，ODT：64.4％）和攻击性患者。据报告ODT-患者为6.5％，SOT患者为2.9％。结论：这项非随机的观察性研究显示，两种奥氮平制剂治疗的患者均具有可比的结果和耐受性。在急性治疗环境中，口腔崩解片优选用于药物接受程度较低的病情较重和侵略性更高的患者。

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