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首页> 外文期刊>Patient Preference and Adherence >Safety, efficacy and patient acceptability of the combined estrogen and progestin transdermal contraceptive patch: a review
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Safety, efficacy and patient acceptability of the combined estrogen and progestin transdermal contraceptive patch: a review

机译：雌激素和孕激素透皮避孕贴剂的安全性，有效性和患者可接受性：综述

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Abstract: The worldwide introduction of the first, unique patch for hormonal contraception (ethinyl estradiolorelgestromin, EE/NGMN patch) was widely recognized as a significant event in the development of drug delivery systems. This innovation offers a number of advantages over the oral route, and extensive clinical trials have proved its safety, efficacy, effectiveness, and tolerability. The weekly administration and ease of use/simplicity of the EE/NGMN patch contribute to its acceptability, and help to resolve the two main problems of non-adherence, namely early discontinuation and inconsistent use. The patch offers additional benefits to adolescents (improvement of dysmenorrhea and acne), adults (improvement in emotional and physical well-being, premenstrual syndrome, and menstrual irregularities), and perimenopausal women (correction of hormonal imbalance, modulation of premenopausal symptoms), thus providing high satisfaction rates (in nearly 90% of users). Since its introduction, the transdermal contraceptive patch has proved to be a useful choice for women who seek a convenient formulation which is easy to use, with additional, non-contraceptive tailored benefits for all the ages.
机译：摘要：激素避孕的首个独特的贴剂（乙炔雌二醇/诺瑞特罗汀，EE / NGMN贴剂）在全球范围内的引入被公认为是药物输送系统发展中的重要事件。这项创新具有比口服途径更多的优势，并且广泛的临床试验证明了其安全性，有效性，有效性和耐受性。 EE / NGMN补丁的每周管理和易用性/简单性有助于其可接受性，并有助于解决两个问题，即早期不遵守和使用不统一，这是不遵守的。该贴片为青少年（改善痛经和痤疮），成年人（改善情绪和身体健康，经前综合症和月经不调）和绝经后妇女（矫正荷尔蒙失调，调节绝经前症状）提供更多好处。提供高满意度（近90％的用户）。自推出以来，经皮避孕贴片已被证明是寻求方便使用且易于使用的配方的女性的有益选择，并且为所有年龄段的女性提供非避孕定制的好处。

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