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首页> 外文期刊>Pathology Research International >Comparison of Immunohistochemical Expression of Antiapoptotic Protein Survivin in Normal Oral Mucosa, Oral Leukoplakia, and Oral Squamous Cell Carcinoma
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Comparison of Immunohistochemical Expression of Antiapoptotic Protein Survivin in Normal Oral Mucosa, Oral Leukoplakia, and Oral Squamous Cell Carcinoma

机译：正常口腔黏膜，口腔白斑和口腔鳞状细胞癌中抗凋亡蛋白survivin免疫组织化学表达的比较

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摘要

Background. Oral squamous cell carcinoma is the sixth most frequent malignant tumor worldwide and the third most common cancers in developing countries. Oral leukoplakia is the best-known precursor lesion of oral squamous cell carcinoma. The aim of the present study was to compare immunohistochemical expression of antiapoptotic protein survivin in normal oral mucosa, oral leukoplakia, and oral squamous cell carcinoma.Method. Total 45 specimens of formalin fixed paraffin embedded tissue blocks, 15 in each of the following: normal oral mucosa, leukoplakia, and oral squamous cell carcinoma were used for the study. Immunohistochemical reaction for survivin protein was performed for the 4 µm thick histological sections taken on positively charged slides.Results. 20% normal mucosa cases, 53.33% cases of leukoplakia, and 80% of oral squamous cell carcinoma were found out to be survivin positive. One way ANOVA test indicated statistically significant difference of survivin expression between the three different groupsp<0.001.Conclusion. A high incidence of survivin protein expression in oral epithelial dysplasia and squamous cell carcinoma samples indicate that survivin protein expression may be an early event in initiation and progression of oral squamous cell carcinoma.
机译：背景。口腔鳞状细胞癌是全球第六大最常见的恶性肿瘤，也是发展中国家的第三大最常见的癌症。口腔白斑是口腔鳞状细胞癌最著名的前体病变。本研究的目的是比较抗凋亡蛋白survivin在正常口腔黏膜，口腔白斑和口腔鳞状细胞癌中的免疫组织化学表达。总共45份福尔马林固定石蜡包埋的组织块标本，以下各15份：正常口腔粘膜，白斑和口腔鳞状细胞癌。在带正电的载玻片上截取的4μm厚的组织切片上进行了survivin蛋白的免疫组织化学反应。发现正常黏膜病例为20％，白斑为53.33％，口腔鳞状细胞癌为80％。一种方法是ANOVA测试表明三个不同组之间的survivin表达在统计上有显着差异p <0.001。在口腔上皮发育不良和鳞状细胞癌样品中survivin蛋白表达的高发生率表明，survivin蛋白表达可能是口腔鳞状细胞癌发生和发展的早期事件。

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