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首页> 外文期刊>Pakistan journal of medical sciences. >Antimicrobial susceptibility patterns of clinical isolates of Pseudomonas aeruginosa isolated from patients of respiratory tract infections in a Tertiary Care Hospital, Peshawar
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Antimicrobial susceptibility patterns of clinical isolates of Pseudomonas aeruginosa isolated from patients of respiratory tract infections in a Tertiary Care Hospital, Peshawar

机译：从白沙瓦三级医院的呼吸道感染患者中分离出的铜绿假单胞菌临床分离株的抗菌药敏模式

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Objective: This study aims to determine the prevalence and susceptibility pattern of Pseudomonas aeruginosa and multidrug-resistant (MDR) isolates in patients suffering from respiratory tract infection.Methods: A cross sectional study was conducted from January to December 2014 in Northwest General Hospital and Research Centre, Peshawar. A total of 615 sputum samples were collected from both in and out-patients. Sputum samples were collected as per standard procedure and were inoculated on Blood, MacConkey and Chocolate agar. The isolates were identified by standard protocols using biochemical tests. The antibiotic susceptibility pattern of each isolate was checked as per Clinical and Laboratory Standards Institute (CLSI) guidelines using Kirby- Bauer’s disc diffusion method.Results: Out of 615 sputum samples, 354 (57.56%) were culture positive. Out of these a total of 71 (20.05%) strains of Pseudomonas were isolated, where 54.93% was from males and 45.07% were from females (Mean age was 44.29 ± 22.72). Highest sensitivity was seen to Amikacin (92.86%) followed by Meropenem (91.55%) while lowest sensitivity was seen to Cefoperazone + Sulbactam (16.9%). There were 39.44% MDR strains, out of which 25% were Extensively Drug Resistant (XDR) and 10.71% were Pan Drug Resistant (PDR). In vitro susceptibility of MDR isolates showed highest sensitivity to Amikacin (82.14%) followed by Carbapenems (78.57%). All MDR isolates were resistant to Cefoperazone + Sulbactam. Resistance to Piperacillin + Tazobactam was 96.43%.Conclusion: Pseudomonas aeruginosa is one of the commonly isolated organisms and it is becoming more resistant to commonly used antibiotics. Carbapenems and aminoglycosides were the two classes of drugs that showed highest activity against Pseudomonas aeruginosa.
机译：目的：本研究旨在确定呼吸道感染患者中铜绿假单胞菌和多药耐药（MDR）分离株的流行情况和易感性方法。方法：2014年1月至2014年12月在西北总医院进行了横断面研究白沙瓦中心。总共从门诊和门诊患者中收集了615份痰标本。按照标准程序收集痰液样本，并接种在Blood，MacConkey和Chocolate琼脂上。通过使用生化测试的标准方案鉴定分离物。根据临床和实验室标准协会（CLSI）的指南，使用柯比鲍尔（Kirby-Bauer）的碟片扩散法检查了每种分离物的抗生素敏感性模式。结果：在615份痰标本中，有354份（57.56％）为培养阳性。在这些菌株中，共分离出71株（20.05％）假单胞菌菌株，其中54.93％来自男性，45.07％来自女性（平均年龄为44.29±22.72）。对阿米卡星的敏感性最高（92.86％），其次是美罗培南（91.55％），而对头孢哌酮+舒巴坦的敏感性最低（16.9％）。有39.44％的MDR菌株，其中25％为广泛耐药性（XDR）和10.71％为泛耐药性（PDR）。 MDR分离物的体外敏感性显示对阿米卡星的敏感性最高（82.14％），其次是碳青霉烯类（78.57％）。所有MDR分离株均对头孢哌酮+舒巴坦具有抗性。对哌拉西林+他唑巴坦的耐药率为96.43％。结论：铜绿假单胞菌是最常见的分离生物之一，对常用抗生素的耐药性也越来越高。碳青霉烯类和氨基糖苷类是对铜绿假单胞菌具有最高活性的两类药物。

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