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首页> 外文期刊>Patient Preference and Adherence >Risk factors for drug nonadherence in antidepressant-treated patients and implications of pharmacist adherence instructions for adherence improvement
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Risk factors for drug nonadherence in antidepressant-treated patients and implications of pharmacist adherence instructions for adherence improvement

机译：抗抑郁药治疗患者药物非依从性的危险因素及药剂师依从性说明对依从性改善的意义

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Background: The aim of this study was to determine the characteristics of drug adherence in antidepressant-treated versus antidepressant-na?ve patients using Drug Attitude Inventory (DAI)-10 scores for nonadherence, to examine the contribution of patient variables such as age, gender, education, prescription contents, side effects, and type of depression (melancholic, nonmelancholic, bipolar) to the reported DAI-10 score, and to examine the efficacy of pharmacist adherence instruction on adherence with antidepressant therapy.Methods: The subjects were 71 antidepressant-treated inpatients (17 with melancholic depression, 35 with nonmelancholic depression, and 19 with bipolar depression) and 80 antidepressant-na?ve inpatients. In the antidepressant-treated patients, self-management of drug intake and pharmacist adherence instruction was initiated after depressive symptoms were in remission, and pharmacist adherence instruction was conducted until the day of discharge.Results: There were no significant differences in baseline characteristics between antidepressant-na?ve and antidepressant-treated patients. In antidepressant-treated patients, the mean DAI-10 total score was significantly lower and awareness of side effects was significantly higher than in antidepressant-na?ve patients who have never taken antidepressants, nor been referred to psychiatry services (according to pharmacist interviews and medical records). On the first day of self-management of drug intake, the DAI-10 total score in patients with melancholic and bipolar depression was significantly lower than that in patients with nonmelancholic depression. On the day of discharge, there was a significant improvement of DAI-10 total score in all antidepressant-treated patients, and the DAI-10 total score in patients with melancholic depression was significantly lower than that in patients with nonmelancholic depression. The limitation of the study was the small sample size and the fact that we followed only acute phase inpatients. However, the findings seem particularly robust in view of this.Conclusion: Risk factors for nonadherence included side effects of antidepressant treatment and type of depression. The results presented here suggest that patients with melancholic depression may be more vulnerable to nonadherence, and that pharmacist adherence instruction may improve nonadherence in antidepressant-treated patients according to type of depression.
机译：背景：这项研究的目的是使用药物态度量表（DAI）-10评分的非依从性，确定抗抑郁药治疗与未接受抗抑郁药的患者的药物依从性特征，以检查患者变量（例如年龄，性别，教育程度，处方内容，副作用和抑郁类型（忧郁，非忧郁，双相情感障碍）与已报告的DAI-10得分相关，并检查药师依从性说明对依从性抗抑郁治疗的疗效。方法：受试者为71名接受抗抑郁药治疗的住院患者（17例患有忧郁症抑郁症，35例患有非忧郁症抑郁症，19例患有双相抑郁症）和80例未接受过抗抑郁药的住院患者。在抗抑郁药治疗的患者中，抑郁症状缓解后开始进行药物自我管理和药剂师的依从性指导，并且直到出院当天都进行了药剂师的依从性指导。结果：抗抑郁药的基线特征无显着差异初治和抗抑郁药治疗的患者。与从未接受过抗抑郁药或从未接受过精神病治疗的未接受过抗抑郁药治疗的初次接受抗抑郁药治疗的患者相比，接受过抗抑郁药治疗的患者的平均DAI-10总得分低得多，并且对副作用的认识显着更高（根据药剂师的访谈和病历）。在自我管理药物摄入的第一天，忧郁和双相情感障碍患者的DAI-10总分明显低于非忧郁性抑郁患者。在出院当天，所有抗抑郁药治疗患者的DAI-10总分都有显着改善，忧郁症患者的DAI-10总分明显低于非忧郁症患者。该研究的局限性在于样本量小以及我们仅追踪急性期患者。结论：结论：不坚持治疗的危险因素包括抗抑郁药的副作用和抑郁症的类型。此处显示的结果表明，忧郁症抑郁症患者可能更容易遭受非依从性的困扰，而药剂师依从性指导可能会根据抑郁症的类型改善抗抑郁药治疗患者的非依从性。

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