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Adherence to lipid-lowering treatment: the patient perspective

机译：坚持降脂治疗：患者的观点

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Abstract: Despite the widespread prescription of highly effective lipid-lowering medications, such as the HMG-CoA reductase inhibitors (statins), a large portion of the population has lipid levels higher than the recommended goals. Treatment failures have been attributed to a variety of causes but the most important is likely to be poor adherence to therapy in the form of irregular or interrupted intake and the high frequency of discontinuation or lack of persistence. Adherence is a multidimensional phenomenon determined by the interplay of patient factors, physician factors, and health care system factors. Patients' knowledge and beliefs about their illness, motivation to manage it, confidence in their ability to engage in illness-management behaviors, and expectations regarding the outcome of treatment and the consequences of poor adherence interact to influence adherence behavior. Patient-related factors account for the largest incremental explanatory power in predicting adherence. This article provides an overview of this critical issue, focusing on patient role in determining adherence level to lipid-lowering therapy.
机译：摘要：尽管已广泛使用高效降脂药物，例如HMG-CoA还原酶抑制剂（他汀类药物），但仍有很大一部分人的血脂水平高于建议的目标。治疗失败归因于多种原因，但最重要的可能是对治疗的依从性差，包括不规则或间断性摄入，中断频繁或缺乏持久性。依从性是一种多维现象，由患者因素，医师因素和医疗保健系统因素之间的相互作用决定。患者对疾病的知识和信念，对疾病的治疗动机，对他们参与疾病管理行为能力的信心以及对治疗结果和依从性差的后果的期望会影响到依从性行为。与患者相关的因素在预测依从性中占最大的解释力。本文提供了此关键问题的概述，重点介绍了患者在确定降脂治疗依从性方面的作用。

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