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首页> 外文期刊>Patient Preference and Adherence >Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill data
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Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill data

机译：通过药房充值数据通过比利时社区药房评估药物依从性，异维A酸的合理使用和避孕

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Purpose: The aims of the study were to evaluate medication adherence and the influencing factors for isotretinoin and contraception (oral, patches, and rings) and to evaluate the concomitant use of contraception and isotretinoin. Methods: Reimbursed prescription data from January 2012 to August 2015 of all patients in Belgium were received from Pharmanet–National Institute for Health and Disability Insurance. Medication adherence was measured according to the medication possession ratio. The influence of gender and age was analyzed using the Mann–Whitney test and the Spearman coefficient correlation. The independence between adherence to contraception and adherence to isotretinoin was analyzed using the Pearson chi-square test of independence. Persistence was defined as the number of days between initiation and presumed end of treatment. The Kaplan–Meier method was used to plot the medication persistence curves, and the log-rank test was used to compare the curves. The concomitant use of contraception and isotretinoin was analyzed using descriptive statistics. Results: The medication possession ratio was ≥0.8 for 46.1% of patients receiving isotretinoin and for 74.0% of women using contraception. For isotretinoin, this percentage decreased as the number of attempts increased (29.8% for the second attempt and 19.8% for more than two attempts). Men seemed more adherent than women, and a weak negative correlation between adherence and age was observed. The adherence data of isotretinoin and contraception were independent. The median persistence for isotretinoin treatment was 139?days (interquartile range 71–209) and was higher for men. Among women between 12 and 21?years old taking isotretinoin, 63.8% received at least one contraceptive prescription. However, 15.7% of women taking isotretinoin adhered to the use of contraception 1?month before, during, and 1?month after treatment. Conclusion: Medication adherence to isotretinoin and contraception and compliance with the isotretinoin safety recommendation could be improved. Health service interventions, using pharmacy refill data, should be delivered to ensure patient safety and strict adherence to contraception when under isotretinoin treatment.
机译：目的：该研究的目的是评估药物依从性以及异维A酸和避孕（口，斑块和环）的影响因素，并评估避孕和异维A酸的同时使用。方法：2012年1月至2015年8月在比利时所有患者的报销处方数据来自Pharmanet-国家健康与残疾保险协会。根据药物占有率测量药物依从性。使用Mann-Whitney检验和Spearman系数相关性分析了性别和年龄的影响。使用皮尔逊卡方独立性检验分析了坚持避孕和坚持异维A酸之间的独立性。持续性定义为开始治疗至预计结束治疗之间的天数。 Kaplan–Meier方法用于绘制药物持久性曲线，对数秩检验用于比较曲线。使用描述性统计数据分析了避孕药和异维A酸同时使用的情况。结果：接受异维A酸治疗的患者中有46.1％的患者和74.0％的使用避孕药的妇女的药物拥有率≥0.8。对于异维A酸，该百分比随着尝试次数的增加而降低（第二次尝试为29.8％，两次以上尝试为19.8％）。男性似乎比女性更具依从性，并且观察到依从性和年龄之间的弱负相关。异维A酸和避孕药的依从性数据是独立的。异维A酸治疗的中位持续时间为139天（四分位间距为71-209），男性更高。在服用异维A酸的12至21岁女性中，有63.8％的人至少接受过一种避孕药。但是，服用异维A酸的妇女中有15.7％在治疗前，治疗中和治疗后1个月坚持使用避孕药。结论：可以提高药物对异维A酸的依从性和避孕率以及对异维A酸安全性建议的依从性。应使用药房补充数据提供卫生服务干预措施，以确保患者安全并在接受异维A酸治疗时严格遵守避孕措施。

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