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首页> 外文期刊>Patient Preference and Adherence >Consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study
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Consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study

机译：消费者相关因素影响单相抑郁患者抗抑郁药依从性的定性研究

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Purpose: To explore factors which facilitate and negatively impact adherence, at initiation, implementation and discontinuation phases of adherence to antidepressant medicines. Patients and methods: Semi-structured, face-to-face interviews were conducted with patients suffering from unipolar depression. The digitally audio-recorded and transcribed verbatim were used. Transcripts were thematically content analyzed and data managed using N-Vivo software. Results: Twenty-three interviews were conducted. The predominant factors facilitating initiation of therapy included self-motivation and severity of depression. Factors aiding persistence with therapy included belief in, and effectiveness of, antidepressants. Stigma and fear of adverse events inhibited initiation of therapy, whilst adverse events and ineffectiveness of antidepressants contributed to discontinuation. Patients with strong perceptions of the necessity and few concerns about antidepressants were more likely to adhere to treatment at all phases of adherence. Conclusion: Different factors influence medication adherence at the different phases of adherence. These factors were based on individual perceptions about depression and its treatment, and actual experiences of antidepressant treatment. This information should be considered by health care professionals in delivering targeted and tailored interventions to foster adherence. Strategies to address medication non-adherence in unipolar depression patients should consider the phase of adherence and individual perceptions about depression and its treatment, along with previous experiences with treatment for depression.
机译：目的：探讨在抗抑郁药物依从性的起始，实施和终止阶段，促进和不利于依从性的因素。患者和方法：对患有单相抑郁症的患者进行半结构式的面对面访谈。使用数字录音和逐字逐字记录。使用N-Vivo软件对成绩单进行主题内容分析和数据管理。结果：进行了23次访谈。促进治疗开始的主要因素包括自我动机和抑郁的严重程度。坚持治疗的因素包括对抗抑郁药的信任和有效性。污名和对不良事件的恐惧抑制了治疗的开始，而不良事件和抗抑郁药的无效导致了治疗的中断。对必要性有强烈认识并且很少担心抗抑郁药的患者更有可能在坚持治疗的所有阶段坚持治疗。结论：在依从性的不同阶段，不同因素会影响药物依从性。这些因素是基于个人对抑郁症及其治疗的认识以及抗抑郁药治疗的实际经验。医护人员在提供针对性和量身定制的干预措施以促进依从性时应考虑这些信息。解决单相抑郁症患者药物非依从性的策略应考虑依从性阶段以及个人对抑郁症及其治疗的看法，以及以往的抑郁症治疗经验。

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