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首页> 外文期刊>Patient Preference and Adherence >Treatment preferences among Japanese women with dysmenorrhea: results from a discrete choice experiment study
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Treatment preferences among Japanese women with dysmenorrhea: results from a discrete choice experiment study

机译：日本女性痛经的治疗偏好：一项离散选择实验研究的结果

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Purpose: To examine patient preferences for oral and intrauterine system treatments for dysmenorrhea in Japan. Patients and methods: A discrete choice experiment was conducted to assess the willingness to accept trade-offs among hypothetical treatment profiles. An internet-based survey was administered to women 18–49 years of age who self-reported a dysmenorrhea diagnosis or experienced dysmenorrhea at least once in the past 6 months (N=309). Choice questions included pairs of treatments presented with different attributes: mode of administration, reduction in bleeding after 6 months, chance of symptoms becoming “improved”, nausea, weight gain, irregular bleeding, and risk of venous thromboembolism. Relative importance (RI) estimates were computed. Results: The mean respondent age was 35.8 years (standard deviation =7.0), and 85 women (27.5%) reported that they had previously used hormonal therapy for dysmenorrhea. Treatment preference was most strongly associated with mode of administration (RI=49.8%), followed by chance of irregular bleeding (RI=17.3%). In contrast, treatment preference was most weakly associated with chance of weight gain (RI=2.4%) and reduction in bleeding after 6 months (RI=0.8%). Respondents preferred oral treatments: for twice-daily regimen, odds ratio (OR)=4.90; for once-daily fixed cyclic regimen, OR=4.20; and for once-daily flexible extended regimen, OR=2.44; whereas for intrauterine system, OR=0.02 ( p 0.001 for all). Those with prior hormonal therapy experience exhibited the same pattern. Conclusion: Mode of administration factored heavily in dysmenorrhea treatment preferences. Women of reproductive age preferred oral medication, especially twice-daily regimen and once-daily fixed cyclic regimen. Findings can potentially help to improve physician–patient communication and treatment decision making. Physicians should consider factors that can influence patient preference to optimize treatment acceptance and adherence.
机译：目的：研究日本对痛经的口服和宫内系统治疗的患者偏好。患者和方法：进行了一项离散选择实验，以评估在假设治疗方案之间接受取舍的意愿。在过去6个月中，至少有一次自我报告痛经诊断或经历过痛经的18-49岁女性进行了基于互联网的调查。选择的问题包括具有不同属性的成对疗法：给药方式，6个月后出血减少，症状“改善”的机会，恶心，体重增加，不规则出血和静脉血栓栓塞的风险。计算相对重要性（RI）估计值。结果：受访者的平均年龄为35.8岁（标准差= 7.0），有85名女性（27.5％）报告他们以前曾使用激素疗法治疗痛经。治疗偏好与给药方式密切相关（RI = 49.8％），其次是不规则出血的可能性（RI = 17.3％）。相反，治疗偏好与体重增加的机会（RI = 2.4％）和6个月后出血减少（RI = 0.8％）的关联最弱。受访者更喜欢口服治疗：对于每天两次的方案，优势比（OR）= 4.90;对于每天一次的固定循环方案，OR = 4.20;对于每天一次的灵活扩展方案，OR = 2.44;而对于子宫内系统，OR = 0.02（所有p <0.001）。那些有激素治疗经验的人表现出相同的模式。结论：痛经治疗的偏爱很大程度上取决于给药方式。育龄妇女更喜欢口服药物，尤其是每天两次的治疗方案和每天一次的固定循环治疗方案。研究结果可能有助于改善医患沟通和治疗决策。医生应考虑可影响患者偏好的因素，以优化治疗的接受度和依从性。

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