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A technology-enabled adherence enhancement system for people with bipolar disorder: results from a feasibility and patient acceptance analysis

机译：技术支持的躁郁症患者依从性增强系统：可行性和患者接受度分析的结果

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Objective: As poor medication adherence is common in bipolar disorder (BD), technology-assisted approaches may help to monitor and enhance adherence. This study evaluated preliminary feasibility, patient satisfaction and effects on adherence, BD knowledge, and BD symptoms associated with the use of a multicomponent technology-assisted adherence enhancement system. Methods: This prospective study tested the system in five BD patients over a 15-day period. System components included: 1) an automated pill cap with remote monitoring sensor; 2) a multimedia adherence enhancement program; and 3) a treatment incentive program. This study evaluated system usability, patient satisfaction and effects on adherence (Morisky scale), knowledge (treatment knowledge test [TKT]), and symptoms (internal state scale [ISS]). Results: Mean age of the sample was 62?years, 4/5 (80%) Caucasian, and 4/5 (80%) single/divorced or widowed. Most participants (4/5, 80%) were on a single BD medication. Participants had BD for an average of 21?years. Challenges included attaching the pill sensor to standard pharmacy bottles for individuals using very large pill containers or those with multiday pill boxes. Three of five (60%) individuals completed the full 15-day period. Usability scores were high overall. Mean Morisky scores improved. Means on all four subscales of the ISS were all in the direction of improvement. On the TKT, there was a 40% increase in mean scores. Conclusion: A multicomponent technology-assisted BD adherence enhancement system is feasible. Challenges include accommodating multiple types of pill containers and monitoring multiple drugs simultaneously. The system can also generate adherence information that is potentially useful for treatment planning.
机译：目的：由于双相情感障碍（BD）中常见的药物依从性差，因此技术辅助方法可能有助于监测和增强依从性。这项研究评估了初步可行性，患者满意度以及对依从性，BD知识和BD症状的影响，这些影响与使用多组分技术辅助依从性增强系统相关。方法：这项前瞻性研究在15天的时间内对五名BD患者进行了系统测试。系统组成包括：1）具有远程监控传感器的自动药丸盒; 2）多媒体依从性增强程序; 3）治疗激励计划。这项研究评估了系统的可用性，患者的满意度以及对依从性（Morisky量表），知识（治疗知识测验[TKT]）和症状（内部状态量表[ISS]）的影响。结果：样本的平均年龄为62岁，白种人为4/5（80％），单身/离婚或丧偶者为4/5（80％）。大多数参与者（4 / 5，80％）使用单一BD药物。参与者患有BD的平均时间为21年。挑战包括将药丸传感器安装到标准药瓶上，以供使用超大药丸容器的人或装有多日药丸盒的人使用。五分之三（60％）的人完成了整个15天的时间。总体上，可用性得分很高。平均Morisky分数有所提高。 ISS的所有四个子量表上的均值都朝着改善的方向发展。在TKT上，平均得分提高了40％。结论：多组分技术辅助的BD依从性增强系统是可行的。挑战包括容纳多种类型的药丸容器并同时监视多种药物。该系统还可以生成可能对治疗计划有用的依从性信息。

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