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首页> 外文期刊>Patient Preference and Adherence >Drug holidays: the most frequent type of noncompliance with calcium plus vitamin D supplementation in persistent patients with osteoporosis
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Drug holidays: the most frequent type of noncompliance with calcium plus vitamin D supplementation in persistent patients with osteoporosis

机译：放假期间：持续性骨质疏松症患者中最常见的不依从钙和维生素D补充的类型

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Purpose: All current recommendations include calcium and vitamin D (Ca–D) as an integrated part of osteoporosis treatment. The purpose of this pilot study was to analyze compliance with a fixed combination of Ca–D in women persistent with the treatment. Patients and methods: An observational study was carried out in three osteocenters in the Czech Republic. Women with osteoporosis ≥55 years of age concurrently treated with oral ibandronate were eligible. Compliance was evaluated in a period of 3 months by Medication Event Monitoring System (MEMS), tablet count, and self-report. Nonpersistence was defined as a MEMS-based gap in the use of Ca–D to be 30 days or more. Results: A total of 73 patients were monitored, of which 49 patients were analyzed (target population). Based on MEMS, mean overall compliance was 71%; good compliance (≥80%) was observed in 59% of the patients. As many as 71% of the patients took drug holidays (≥3 consecutive days without intake); overall compliance of these patients was 59% and was slightly lower on Fridays and weekends. Patients without drug holidays were fully compliant (did not omit individual doses). Compliance differed according to daily time at which the patients mostly used the Ca–D. Afternoon/evening takers showed a mean overall compliance of 82% while morningight takers only 51% ( P =0.049). Based on MEMS, tablet count, and self-report, compliance?≥75% was observed in 59%, 100%, and 87% of the patients, respectively. Outcomes obtained by the three methods were not associated with each other. Undesirable concurrent ingestion of Ca–D and ibandronate was present only twice. Conclusion: Despite almost perfect self-reported and tablet count-based compliance, MEMS-based compliance was relatively poor. Consecutive supplementation-free days were common; more than two-thirds of the patients took at least one drug holiday. This pilot study showed drug holiday to be the most important type of noncompliance with Ca–D in those who are persistent with the treatment.
机译：目的：目前所有建议都将钙和维生素D（Ca–D）纳入骨质疏松症治疗的组成部分。这项初步研究的目的是分析坚持治疗的女性对Ca-D固定组合的依从性。患者和方法：在捷克共和国的三个骨中心进行了一项观察性研究。骨质疏松症≥55岁且同时口服伊班膦酸治疗的妇女符合条件。通过药物事件监测系统（MEMS），药片计数和自我报告，在3个月内评估了依从性。非持久性被定义为使用Ca–D的基于MEMS的间隙为30天或更长时间。结果：共监测了73例患者，其中49例被分析（目标人群）。基于MEMS，平均总体合规率为71％;在59％的患者中观察到良好的依从性（≥80％）。多达71％的患者接受了放假（连续3天以上且未摄入药物）;这些患者的总体依从性为59％，在周五和周末略低。没有放假的患者是完全依从的（没有省略个人剂量）。根据患者每天使用Ca-D的时间不同，依从性也有所不同。下午/晚上服用者的平均总体依从性为82％，而早上/晚上服用者只有51％（P = 0.049）。根据MEMS，平板电脑数量和自我报告，分别在59％，100％和87％的患者中观察到依从性≥75％。通过三种方法获得的结果彼此不相关。不良的同时摄入Ca–D和伊班膦酸盐的情况仅出现两次。结论：尽管自我报告和基于平板电脑计数的合规性近乎完美，但基于MEMS的合规性却相对较差。连续的无补充日很常见;超过三分之二的患者至少休了一次假。这项初步研究表明，在坚持治疗的患者中，休假是最重要的不遵守Ca–D的类型。

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