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首页> 外文期刊>Patient Preference and Adherence >Adherence to fingolimod in multiple sclerosis: an investigator-initiated, prospective, observational, single-center cohort study
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Adherence to fingolimod in multiple sclerosis: an investigator-initiated, prospective, observational, single-center cohort study

机译：坚持芬戈莫德在多发性硬化症中的作用：一项由研究者发起的前瞻性观察性单中心队列研究

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Objectives: Adherence to multiple sclerosis (MS) treatment is essential to optimize the likelihood of full treatment effect. This prospective, observational, single-center cohort study investigated adherence to fingolimod over the 2 years following treatment initiation. Two facets of adherence – implementation and persistence – were examined and compared between new and experienced users of disease-modifying treatments (DMTs). Materials and methods: Implementation rates were based on the proportion of days covered and calculated as percentages per half-yearly visits and over 2 years, captured through refill data, pill count, and self-report. Nonadherence was defined as taking less than 85.8% of prescribed pills. Implementation rates were classified as nonadherent (1–3 98.51%–98.7%) and did not change significantly over time; 89% of measurements were in the optimally adherent category, 45.6% in the perfectly adherent category. There was one single occurrence of nonadherence. New users of DMTs were 1.29 times more likely to be adherent than experienced users (OR 1.29, 95% CI 1.11–1.51; P <0.001), but not more persistent. Nineteen of 98 patients discontinued fingolimod. Conclusion: The very high implementation rates displayed in this sample of MS patients suggest that facilitation by health care professionals in preserving adherence behavior may be sufficient for the majority of patients. Targeted interventions should focus on patients who are nonadherent or who stop treatment without intention to reinitiate.
机译：目的：坚持多发性硬化症（MS）治疗对于优化充分治疗效果的可能性至关重要。这项前瞻性，观察性，单中心队列研究调查了治疗开始后2年内对芬戈莫德的依从性。研究人员对坚持治疗的两个方面（实施和坚持）进行了比较，并在新的和经验丰富的疾病缓解疗法（DMT）用户之间进行了比较。材料和方法：实施率是基于覆盖天数的比例，并通过补充数据，药丸计数和自我报告获得，以每半年就诊和2年以上的百分比计算。不坚持被定义为服用少于处方药的85.8％。实施率被归类为不遵守（1-3％98.51％–98.7％），并且随着时间的推移并没有显着变化; 89％的测量值属于最佳粘附力类别，45.6％的粘附力属于最佳粘附力类别。发生了一次不遵守的情况。 DMT的新用户遵守的可能性是有经验的用户的1.29倍（OR 1.29，95％CI 1.11–1.51; P <0.001），但并不持久。 98名患者中有19名停用芬戈莫德。结论：在该MS患者样本中显示的很高的实施率表明，医疗保健专业人员在保持依从性行为方面的促进可能对于大多数患者而言已经足够。有针对性的干预措施应针对没有坚持治疗或无意重新开始治疗的患者。

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