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首页> 外文期刊>Patient Preference and Adherence >Collagenase Clostridium histolyticum in the treatment of Peyronie’s disease: patient selection and perspectives
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Collagenase Clostridium histolyticum in the treatment of Peyronie’s disease: patient selection and perspectives

机译：胶原酶溶组织梭状芽孢杆菌治疗佩罗尼氏病：患者的选择和观点

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摘要

The safety and efficacy of the use of collagenase Clostridium histolyticum (CCH) for the treatment of Peyronie’s disease has been confirmed over the past several years. However, identification of the ideal patient population for use of this treatment is not well established. Multiple studies have attempted to delineate various patient-specific factors that may predict response to treatment with CCH, with the intent of enhancing patient selection. To date, these include baseline curvature severity, duration of disease, disease phase at presentation, plaque calcification, baseline erectile function, plaque size, age, comorbid diabetes, previous penile trauma, responsiveness to first treatment cycle, baseline penile shortening or pain, prior treatment with intralesional injection, compliance with plaque modeling, and atypical curvature. In addition, other studies have sought to explore various aspects of treatment with CCH that may affect patient perspective of treatment. They have focused on patient-reported outcomes, female partner considerations, cost of treatment, and potential confounders of patient satisfaction. This review provides a summary and analysis of currently available literature on topics of patient selection and perspectives in regard to treatment of Peyronie’s disease with CCH.
机译：在过去的几年中，已经证实了使用胶原酶组织溶解梭状芽胞杆菌（CCH）治疗佩罗尼氏病的安全性和有效性。但是，对于使用这种治疗方法的理想患者人群的鉴定尚不完善。多项研究试图描述各种可以预测对CCH治疗反应的患者特异性因素，目的是增强患者选择。迄今为止，这些因素包括基线弯曲严重度，疾病持续时间，就诊时的疾病阶段，斑块钙化，基线勃起功能，斑块大小，年龄，合并症糖尿病，先前的阴茎外伤，对第一个治疗周期的反应，基线阴茎缩短或疼痛，先前病灶内注射治疗，符合斑块模型和非典型曲率。此外，其他研究试图探索可能影响患者治疗角度的CCH治疗的各个方面。他们专注于患者报告的结果，女性伴侣的考虑因素，治疗费用以及患者满意度的潜在混杂因素。这篇评论总结和分析了有关患者选择的话题以及有关使用CCH治疗佩罗尼氏病的观点的现有文献。

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