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Patients’ conceptions of their own influence on good treatment response to biological therapy in chronic inflammatory arthritis

机译：患者对慢性炎症性关节炎生物治疗的良好治疗反应的影响

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Background: Biological therapies are common in the treatment of patients with chronic inflammatory arthritis (CIA). However, despite the fact that many patients respond well to their biological therapies, there are still a number of nonresponders. In order to design the best care for patients, it is important to understand how they conceive their own role in their treatment response. Objective: To explore how patients with CIA conceive their own influence on a good treatment response to biological therapy. Methods: This study had an exploratory and descriptive design with a phenomenographic approach. Interviews were conducted with 25 patients (11 women and 14 men) aged 17–79?years, with CIA who were undergoing biological therapy and who had low disease activity or were in remission. Results: Patients with CIA undergoing biological therapy conceived their own influence on good treatment response in terms of adherence, physical activity, mental attitude, social support, and self-awareness. Adherence was described as the foundation for the patients’ own influence on good treatment response. Physical activity, mental attitude, and social support reflected three essential ways of understanding patients’ influence on good treatment response where the patients spoke about physical strength, mental strength, and social strength. Self-awareness reflected a comprehensive way of influencing good treatment response in which patients balanced their physical, mental, and social resources in partnership with health care professionals. Conclusion: Patients conceived that they had a responsibility for adhering to the treatment as well as achieving balance in life in order to ensure good treatment response. Self-awareness was essential for maintaining a good treatment response, and this reflected the patients’ awareness of the complexity of living their lives with a chronic illness.
机译：背景：生物疗法在治疗慢性炎性关节炎（CIA）患者中很普遍。然而，尽管许多患者对其生物疗法反应良好，但仍然有许多无反应者。为了设计对患者的最佳护理，重要的是要了解他们如何看待自己在治疗反应中的作用。目的：探讨中枢神经系统（CIA）患者如何看待自己对良好的生物治疗反应的影响。方法：本研究采用现象学方法进行探索性和描述性设计。采访了25位年龄在17-79岁之间的患者（11名女性和14名男性），其中有接受过生物疗法且疾病活动低或缓解的CIA患者。结果：接受过生物疗法的CIA患者在坚持，身体活动，心理态度，社会支持和自我意识方面对良好的治疗反应产生了自己的影响。坚持治疗被描述为患者自身对良好治疗反应的影响的基础。身体活动，心理态度和社会支持反映了三种了解患者对良好治疗反应的影响的基本方法，其中患者谈论身体力量，精神力量和社会力量。自我意识反映了影响良好治疗反应的一种综合方法，在这种方法中，患者与医疗保健专业人员合作可以平衡其身体，精神和社会资源。结论：患者认为他们有责任坚持治疗并实现生活平衡，以确保良好的治疗反应。自我意识对于维持良好的治疗反应至关重要，这反映出患者对患有慢性病的生活复杂性的认识。

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