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Patterns of non-adherence to oral antiretroviral medication: frequencies of consecutively missed doses

机译：不坚持口服抗逆转录病毒药物的模式：连续错过剂量的频率

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Purpose: The therapeutic effect of a once-daily oral drug will be maintained if there are nooccurrences of consecutively missed doses that exceed the duration of the drug’s effect. Thedurations of effect of antiretroviral drugs are typically in the range of 1–4 days. Here, we reportthe observed frequencies of $2, $3, and $4 consecutively missed doses for patients taking aonce-daily oral antiretroviral drug for HIV infection.Patients and methods: Medication Event Monitoring System (MEMS) data were extractedfrom an electronic database of MEMS records, for a 30-day period for 555 patients taking oncedailyoral HIV drug therapy. We recorded the number of days with missed doses and occurrencesof $2, $3, or $4 consecutively missed doses. Distributions of the observed frequenciesof $2, $3, and $4 consecutively missed doses as a proportion of number of missed doses werecompared to calculated random distributions using the Wilcoxon signed-rank test.Results: The frequencies of 0, 1, and $2 missed daily doses were 0.279, 0.312, and 0.409,respectively. The frequencies of $2, $3, and $4 consecutively missed doses were 0.184, 0.110,and 0.065, respectively. The probabilities that the observed frequencies of $2, $3, and $4consecutively missed doses were as expected from random chance were P=0.345, P,0.01,and P,0.01, respectively.
机译：目的：如果连续出现的剂量不超过药物作用持续时间的话，将维持每日一次口服药物的治疗作用。抗逆转录病毒药物的作用持续时间通常为1-4天。在此，我们报告观察到每天服用一次口服抗逆转录病毒药物治疗HIV感染的患者连续2、3和4美元的服药频率。 555名患者接受了每日一次的HIV药物治疗，为期30天。我们记录了错过服药的天数以及连续$ 2，$ 3或$ 4的不服药次数。使用Wilcoxon符号秩检验，将连续观察到的$ 2，$ 3和$ 4的服药频率与未服药数量的比例与计算的随机分布进行比较。结果：每日服药的0、1和$ 2服药频率分别为分别为0.279、0.312和0.409。 $ 2，$ 3和$ 4的连续错过剂量的频率分别为0.184、0.110和0.065。观察到的连续$ 2，$ 3和$ 4连续服药频率与随机机会所期望的概率分别为P = 0.345，P，0.01和P，0.01。

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