Zinc deficiency has demonstrated an association with the risk of asthma. This study aimed to evaluate the efficacy of zinc supplementation in reducing the severity of childhood asthma exacerbation. A number of 42 children with asthma exacerbation admitted to the hospital were randomized to receive either zinc bis-glycinate (30 mg elemental zinc/day) or a placebo in adjuvant to the standard treatment. The pediatric respiratory assessment measure (PRAM) was used to measure the asthma severity. The primary outcome was a change in asthma severity from the baseline to the end of study. The study found that PRAM score in the zinc group showed a more rapid decrease compared to the control group at the 24-hour (2.2±1.3 vs. 1.2±1.3; P=0.015) and 48-hour (3.4±2.0 vs. 2.2±1.8; P=0.042) intervals. At admission, overall mean serum zinc level was 63.8 mg/dL and 57.1% of children had zinc deficiency with no difference in prevalence between groups. PRAM scores did not differ between children with low and normal zinc status. In conclusion, zinc supplementation as the adjuvant therapy to the standard treatment during asthma exacerbation resulted in rapid lessening of severity.
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机译：锌缺乏已证明与哮喘风险有关。这项研究旨在评估补锌在降低儿童哮喘急性发作的严重程度方面的功效。入院的42例哮喘急性发作儿童被随机分配接受双甘氨酸锌（每天30 mg元素锌）或安慰剂作为标准治疗的辅助药物。儿科呼吸评估指标（PRAM）用于衡量哮喘的严重程度。主要结果是从基线到研究结束之间哮喘严重程度的变化。研究发现锌组的PRAM得分在24小时（2.2±1.3 vs. 1.2±1.3; P = 0.015）和48小时（3.4±2.0 vs. 2.2）较对照组更快地下降。 ±1.8; P = 0.042）时间间隔。入院时，总体平均血清锌水平为63.8 mg / dL，57.1％的儿童缺锌，两组之间的患病率无差异。锌水平低和正常的儿童之间的PRAM分数没有差异。总之，在哮喘急性发作期间补充锌作为标准治疗的辅助疗法可导致严重程度迅速减轻。
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