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首页> 外文期刊>Pediatrics Neonatology >Predictors of Booster Response to Hepatitis B Vaccine at 15 years of age: A Cross-Sectional School-Based Study
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Predictors of Booster Response to Hepatitis B Vaccine at 15 years of age: A Cross-Sectional School-Based Study

机译：15岁以下对乙型肝炎疫苗加强免疫应答的预测因子：一项基于学校的跨部门研究

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Background: The current consensus does not support the use of booster dose because of its anamnestic response in almost all children 15 years after universal infant hepatitis B virus (HBV) vaccination. However, in our clinical setting, numerous concerned parents request a booster administration for their children. We aimed to provide the possible predictors of booster response in adolescents before this booster administration. Methods: This study comprised a series of cross-sectional serological surveys of HBV markers in 15-year-old individuals between 2008 and 2012. Data on serum hepatitis B surface antigen, hepatitis B surface antibody (anti-HBs), and liver-function biomarkers in a total of 887 senior high-school students were collected. There were two parts to this study: HBV seroepidemiology and booster-response analysis to identify the possible response predictors and decay factors after the HBV booster administration. Results: The overall anti-HBs and hepatitis B surface antigen seropositivity rates were 34.7% and 0.7%, respectively, and the median anti-HBs titer was 3.3 mIU/mL. Six weeks after one dose of recombinant HBV vaccine, the overall booster-response rate in the double-seronegative recipients was 94% (471/501). Among the participants whose initial anti-HBs titers were undetectable or low, 72.4% (247/341) and 95.6% (153/160), respectively, reactivated their anti-HBs titers >= 100 mIU/mL about 6 weeks after the booster administration. The likelihood of postbooster anti-HBs titer reaching an adequate protective level increased with the prebooster titer. The female participants had stronger anamnestic responses compared to the male participants. Conclusion: We found that the female participants and prebooster anti-HBs titers above the detection limit of the immunoassay were good predictors of HBV booster response.
机译：背景：目前的共识不支持使用加强剂量，因为在婴儿通用乙型肝炎病毒（HBV）疫苗接种15年后的几乎所有儿童中，其记忆消除反应均如此。但是，在我们的临床环境中，许多相关的父母要求对孩子进行加强免疫治疗。我们旨在提供在加强免疫治疗之前青少年加强免疫应答的可能预测指标。方法：这项研究包括一系列横断面血清学调查，调查对象为2008年至2012年间15岁的HBV标记物。血清乙肝表面抗原，乙肝表面抗体（抗HBs）和肝功能的数据共收集了887名高中生的生物标志物。这项研究分为两个部分：HBV血清流行病学和加强反应分析，以确定在加强HBV施用后可能的反应预测因子和衰减因子。结果：总体抗-HBs和乙型肝炎表面抗原血清阳性率分别为34.7％和0.7％，中位抗-HBs滴度为3.3 mIU / mL。一剂重组HBV疫苗注射六周后，双血清阴性接受者的总体加强免疫应答率为94％（471/501）。在最初的抗-HBs滴度无法检测或较低的参与者中，分别在加强免疫后约6周分别恢复了72.4％（247/341）和95.6％（153/160）的抗-HBs滴度> = 100 mIU / mL。行政。增强后的抗-HBs滴度达到增强保护水平的可能性随增强前的滴度的增加而增加。与男性参与者相比，女性参与者具有更强的记忆消除反应。结论：我们发现女性参与者和高于免疫测定法检出限的booster前抗-HBs滴度是HBV加强反应的良好预测指标。

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