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首页> 外文期刊>Pathogens >Interactions between Neutrophils and Pseudomonas aeruginosa in Cystic Fibrosis
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Interactions between Neutrophils and Pseudomonas aeruginosa in Cystic Fibrosis

机译：中性粒细胞与铜绿假单胞菌在囊性纤维化中的相互作用

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Cystic fibrosis (CF) affects 70,000 patients worldwide. Morbidity and mortality in CF is largely caused by lung complications due to the triad of impaired mucociliary clearance, microbial infections and chronic inflammation. Cystic fibrosis airway inflammation is mediated by robust infiltration of polymorphonuclear neutrophil granulocytes (PMNs, neutrophils). Neutrophils are not capable of clearing lung infections and contribute to tissue damage by releasing their dangerous cargo. Pseudomonas aeruginosa is an opportunistic pathogen causing infections in immunocompromised individuals. P. aeruginosa is a main respiratory pathogen in CF infecting most patients. Although PMNs are key to attack and clear P. aeruginosa in immunocompetent individuals, PMNs fail to do so in CF. Understanding why neutrophils cannot clear P. aeruginosa in CF is essential to design novel therapies. This review provides an overview of the antimicrobial mechanisms by which PMNs attack and eliminate P. aeruginosa. It also summarizes current advances in our understanding of why PMNs are incapable of clearing P. aeruginosa and how this bacterium adapts to and resists PMN-mediated killing in the airways of CF patients chronically infected with P. aeruginosa.
机译：囊性纤维化（CF）影响全球70,000名患者。 CF的发病率和死亡率主要是由于粘膜纤毛清除力受损，微生物感染和慢性炎症三联征引起的肺部并发症所致。囊性纤维化气道炎症是由多形核嗜中性粒细胞（PMN，嗜中性粒细胞）的强烈浸润介导的。中性粒细胞不能清除肺部感染，并通过释放危险货物而造成组织损伤。铜绿假单胞菌是机会病原体，可引起免疫功能低下的个体感染。铜绿假单胞菌是CF中感染大多数患者的主要呼吸道病原体。尽管PMN是攻击和清除具有免疫能力的个体中铜绿假单胞菌的关键，但PMN在CF中不能做到。理解为什么中性粒细胞不能清除CF中的铜绿假单胞菌对设计新疗法至关重要。这篇综述概述了PMN攻击并消除铜绿假单胞菌的抗菌机制。它还总结了我们在理解PMN为什么不能清除铜绿假单胞菌以及这种细菌如何适应和抵抗PMN介导的慢性感染铜绿假单胞菌的患者气道中的杀伤方面的最新进展。

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