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首页> 外文期刊>Pediatric Health, Medicine and Therapeutics >Diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in Tigray, Ethiopia: retrospective observational study
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Diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in Tigray, Ethiopia: retrospective observational study

机译：埃塞俄比亚提格里新诊断的1型糖尿病儿童和青少年的糖尿病酮症酸中毒：回顾性观察研究

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Background: Diabetic ketoacidosis (DKA) is the most severe acute complication of type 1 diabetes mellitus which results in increased risk of morbidity and mortality especially in developing countries. Objective: To assess prevalence and associated factors of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in hospitals of the Tigray region, Ethiopia. Methods: A facility based retrospective observational study design was conducted in newly diagnosed type 1 diabetic children and adolescents up to the age of 18 years who were registered in 13 general and two referral hospitals from January 1, 2013 to December 30, 2017. The diagnosis of diabetic ketoacidosis was made with the criteria below, Children presenting with polysymptoms, weight loss, vomiting, dehydration, and also the indirect signs or effects of acidosis on respiratory and central nervous systems like Kussmaul breathing, lethargy or coma and biochemically random blood sugar level 11 ml/L, glucosuria and urine ketone +1 and diagnosed with type 1 diabetes for the first time. Descriptive, Mann–Whitney U and logistic regression analysis were carried out to describe and identify the associated factors with diabetic ketoacidosis. Results: More than three-quarters, 258/328 (78.7%) of the newly diagnosed type 1 diabetes patients, presented with diabetic ketoacidosis at initial diagnosis. Median age of diabetic ketoacidosis patients was 11 years. The patients with diabetic ketoacidosis were younger than nondiabetic ketoacidosis patients (11 vs 13 years, P =0.002). The mortality rate of diabetic ketoacidosis was 4.3%. Young age, presence of precipitating factors and symptoms of DKA/diabetes were found to be highly associated with diabetic ketoacidosis at initial diagnosis. Conclusions: The prevalence of diabetic ketoacidosis was alarmingly high. Young age group patients, precipitating factors and the presence of symptoms of diabetes/DKA like excessive drinking, vomiting and fatigue were highly associated with diabetic ketoacidosis.
机译：背景：糖尿病酮症酸中毒（DKA）是1型糖尿病最严重的急性并发症，特别是在发展中国家，这导致发病和死亡的风险增加。目的：评估埃塞俄比亚提格雷地区医院新诊断的1型糖尿病儿童和青少年糖尿病酮症酸中毒的患病率及其相关因素。方法：从2013年1月1日至2017年12月30日，在13家综合医院和两家转诊医院登记的18岁以下初诊1型糖尿病儿童和青少年中进行了基于设施的回顾性观察研究设计。糖尿病酮症酸中毒的评估标准如下：儿童表现出多症状，体重减轻，呕吐，脱水，以及酸中毒对呼吸和中枢神经系统的间接体征或影响，例如库斯莫尔呼吸，嗜睡或昏迷以及生化随机血糖水平> 11 ml / L，糖尿和尿酮> +1，首次诊断为1型糖尿病。描述性，Mann-Whitney U和逻辑回归分析用于描述和确定与糖尿病性酮症酸中毒相关的因素。结果：在新诊断的1型糖尿病患者中，超过四分之三的258/328（78.7％）在初诊时出现糖尿病性酮症酸中毒。糖尿病酮症酸中毒患者的中位年龄为11岁。糖尿病酮症酸中毒的患者比非糖尿病酮症酸中毒的患者年轻（11岁vs 13岁，P = 0.002）。糖尿病酮症酸中毒的死亡率为4.3％。在初诊时，发现年轻年龄，促发因素的存在和DKA /糖尿病的症状与糖尿病性酮症酸中毒高度相关。结论：糖尿病酮症酸中毒的发生率高得惊人。青年组患者，促发因素以及糖尿病/ DKA症状的存在，如过量饮酒，呕吐和疲劳与糖尿病酮症酸中毒高度相关。

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