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Intestinal parasites infections in hospitalized AIDS patients in Kinshasa, Democratic Republic of Congo

机译：刚果民主共和国金夏沙住院的艾滋病患者的肠道寄生虫感染

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To determine the prevalence and the species spectrum of intestinal parasites (IP) involved in hospitalized AIDS patients, a prospective observational and cross-sectional study was carried out in the four main hospitals in Kinshasa, Democratic Republic of the Congo. From November 2006 through September 2007, a single stool sample was collected from 175 hospitalized AIDS patients older than 15 years. Parasites were detected by light microscopy, including Ziehl-Neelsen, Fungi-Fluor, modified trichrome stains, and by immunofluorescence antibody tests and PCR for species diagnosis of microsporidia. At baseline, 19 patients (10.8 %) were under antiretroviral therapy and 156 (89.2 %) were eligible for ART. The main diagnosis for justifying hospitalization was intestinal infection associated with diarrhea in 87 out of 175 (49.7 %). 47 out of 175 (26.9 %) were found to harbor an IP, and 27 out of 175 (15.4 %) were infected with at least one opportunistic IP (OIP). Prevalence rate for OIP were 9.7 %, 5.1 %, 1.7 % and 0.6 % for Cryptosporidium sp., Enterocytozoon bieneusi, Isospora belli and Encephalitozoon intestinalis respectively. Considering patients with diarrhea only, prevalence rate were 12.6 %, 4.6 %, 3.4 % and 1.1 % respectively. The other IP observed were Entamoeba histolytica/Entamoeba dispar in nine cases (5.1 %), Ascaris lumbrico?des in seven cases (4.0 %), Giardia intestinalis in three cases (1.7 %), hookworm in two cases (1.1 %) and Trichiuris trichiura, Enterobius vermicularis, Schistosoma mansoni in one patient each (0.6 %). No significant relationship was established between any individual IP and diarrhea. These results underline the importance of OIP in symptomatic AIDS patients regardless of diarrhea at the time of the hospitalisation, and showed that routine microscopic examination using stains designed for Cryptosporidium spp. or the microsporidia should be considered due to the absence of clinical markers.
机译：为了确定住院的艾滋病患者中肠道寄生虫（IP）的患病率和种类谱，在刚果民主共和国金沙萨的四家主要医院进行了前瞻性观察和横断面研究。从2006年11月到2007年9月，从175名15岁以上的住院AIDS患者中收集了一个粪便样本。通过光学显微镜检测寄生虫，包括Ziehl-Neelsen，真菌-荧光，改良的三色染色剂，并通过免疫荧光抗体测试和PCR进行微孢子虫的物种诊断。基线时，接受抗逆转录病毒治疗的患者为19名（10.8 ％），接受抗逆转录病毒治疗的患者为156名（89.2 ％）。 175例中有87例的肠道感染与腹泻有关，是住院治疗的主要诊断依据（49.7 ％）。 175个中的47个（26.9 ％）被发现具有IP，175个中的27个（15.4 ％）被至少一个机会性IP（OIP）感染。隐孢子虫，比氏肠小肠虫，贝氏伊索菌和肠小脑虫的OIP患病率分别为9.7％，5.1％，1.7％和0.6％。仅考虑腹泻患者，患病率分别为12.6％，4.6％，3.4％和1.1％。观察到的其他IP分别为9例（5.1 ％）致病性变形杆菌/ Entamoeba dispar，7例（4.0 ％）的A虫，3例肠贾第鞭毛虫（1.7 ％），2例钩虫（1.1％）。 ％）和Trichiuris trichiura，Enterobius vermicularis，曼氏血吸虫（1％）。在任何个人IP和腹泻之间没有建立显着的关系。这些结果强调了OIP在有症状的AIDS患者中无论住院时是否腹泻的重要性，并表明常规显微镜检查使用了为隐孢子虫设计的染色剂。或由于没有临床指标而应考虑微孢子虫。

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