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A role for CD4+ and CD8+ cells and not for CD25+ cells in the control of Plasmodium berghei Anka blood stage parasites in rats

机译：CD4 +和CD8 +细胞而不是CD25 +细胞在大鼠伯氏疟原虫Anka血阶段寄生虫控制中的作用

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In previous studies of the infection of rats by P. berghei Anka, we have shown that primary blood stage infection induced the expansion of CD4+ T cells and CD8+ T cells in adult resistant rats while the number of CD4+CD25+ cells was found to be higher in young susceptible rats. In this work, the respective contribution of each cell population was determined in young and adult rats treated with monoclonal antibodies. Down-regulation of surface CD25 molecules, including those expressed by CD4+ cells did not significantly enhance the capacity of young rats to control the development of erythrocytic stages or modify the course of infection in adult infected rats. However, we observed a significant loss of protection when adult rats were treated with anti-CD4 mAb (W3/25) with higher blood parasitemia levels and ~ 50% of rats succumbed to infection. More importantly and in contrast to earlier studies performed in mice, we found a significant increase in blood parasite levels and a significant delay in parasite clearance in adult rats treated with anti-CD8 mAb OX8, known to deplete CD8+ cells. These results suggest that CD8+ cells play a critical role in the development of immune responses in rats to control the replication of blood stage parasites.
机译：在先前对伯氏疟原虫感染大鼠的研究中，我们发现原发性血液阶段感染可诱导成年抗性大鼠CD4 + T细胞和CD8 + T细胞的扩增，而发现CD4 + CD25 +细胞的数量更高在年轻的易感大鼠中。在这项工作中，确定了用单克隆抗体治疗的年轻和成年大鼠中每个细胞群的各自贡献。下表面CD25分子（包括CD4 +细胞表达的分子）的下调并没有显着增强幼鼠控制成年红细胞阶段发育或改变感染过程的能力。但是，我们观察到成年大鼠接受具有更高血液寄生虫水平的抗CD4 mAb（W3 / 25）治疗，约有50％的大鼠死于感染。更重要的是，与在小鼠中进行的早期研究相比，我们发现，用抗CD8 mAb OX8处理的成年大鼠血液中的寄生虫水平显着增加，并且寄生虫清除显着延迟，已知这会消耗CD8 +细胞。这些结果表明，CD8 +细胞在大鼠免疫反应的发展中起着至关重要的作用，以控制血阶段寄生虫的复制。

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